Molecular biology techniques : a classroom laboratory manual /

Molecular Biology Techniques: A Classroom Laboratory Manual, Fourth Edition is a must-have collection of methods and procedures on how to create a single, continuous, comprehensive project that teaches students basic molecular techniques. It is an indispensable tool for introducing advanced undergra...

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Bibliographic Details
Main Authors: Carson, Sue (Susan) (Author), Miller, Heather B. (Author), Srougi, Melissa C. (Author), Witherow, D. Scott (Author)
Corporate Author: ScienceDirect (Online service)
Format: eBook
Language:English
Published: London, United Kingdom : Academic Press, an imprint of Elsevier, 2019.
Edition:Fourth edition.
Subjects:
Online Access:Connect to the full text of this electronic book

MARC

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245 1 0 |a Molecular biology techniques :  |b a classroom laboratory manual /  |c Susan Carson, Heather B. Miller, D. Scott Witherow, Melissa C. Srougi. 
250 |a Fourth edition. 
264 1 |a London, United Kingdom :  |b Academic Press, an imprint of Elsevier,  |c 2019. 
300 |a 1 online resource 
336 |a text  |b txt  |2 rdacontent 
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500 |a Includes index. 
588 0 |a Online resource; title from PDF title page (ScienceDirect, viewed March 14, 2019). 
504 |a Includes bibliographical references and index. 
520 |a Molecular Biology Techniques: A Classroom Laboratory Manual, Fourth Edition is a must-have collection of methods and procedures on how to create a single, continuous, comprehensive project that teaches students basic molecular techniques. It is an indispensable tool for introducing advanced undergraduates and beginning graduate students to the techniques of recombinant DNA technology--or gene cloning and expression. The techniques used in basic research and biotechnology laboratories are covered in detail. Students will gain hands-on experience on subcloning a gene into an expression vector straight through to the purification of the recombinant protein. 
505 0 |a Part I. Manipulation of DNA -- Getting oriented: practicing with micropipettes -- Purification and digestion of plasmid (vector) DNA -- Completion of vector preparation and polymerase chain reaction amplification of egfp -- Preparation on insert DNA (egfp) PCR product -- DNA ligation and transformation of Escherichia coli -- Part II. Screening transformants -- Screening of transformants, part I -- Screening of transformants, part II -- Analysis of DNA sequence from a positive clone -- Part III. Expression, detection, and purification of recombinant proteins from bacteria -- Expressions of fusion protein from positive clones, SDS-PAGE and Western Blot: Part I -- Expressions of fusion protein from positive clones, SDS-PAGE and Western Blot: Part II -- Extraction of recombinant protein from Escherichia coli using a glutathione affinity culture -- Analysis of purification fractions -- Part IV. Analysis of mRNA levels -- Total RNA purification -- Analysis of gst:egfp mRNA levels by RT-qPCR: Part I -- Analysis of gst:egfp mRNA levels by RT-qPCR: Part II -- Analysis of gst:egfp mRNA levels by semiquantitative RT-PCR, Part I -- Analysis of gst:egfp mRNA levels by semiquantitative RT-PCR, Part II -- Part V. Modulation of gene expression -- Culturing mammalian cells -- Transient transfection of mammalian cells -- RNAi-mediated knockdown of EGFP, Part I -- RNAi-mediated knockdown of EGFP, Part II -- RNAi-mediated knockdown of EGFP, Part III -- CRISPR-mediated knockout of EGFP, Part I -- CRISPR-mediated knockout of EGFP, Part II -- Advanced CRISPR, Part I -- Advanced CRISPR, Part II -- Interim laboratory session -- Advanced CRISPR, Part III -- Advanced CRISPR, Part IV -- Advanced CRISPR, Part V -- Advanced CRISPR, Part VI. 
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700 1 |a Miller, Heather B.,  |e author. 
700 1 |a Srougi, Melissa C.,  |e author. 
700 1 |a Witherow, D. Scott,  |e author. 
710 2 |a ScienceDirect (Online service) 
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