rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Epigenetics of chronic pain
  name:
    name part: Bai, Guang
    role:
      role term: editor.
  name:
    name part: Ren, Ke
    role:
      role term: editor.
  name:
    name part: ScienceDirect (Online service)
  type of resource: text
  genre: bibliography
  genre: Electronic books.
  genre: Internet Resources.
  origin info:
    place:
      place term: enk
    date issued: 2019
    copyright date: 2019
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource
  abstract: Epigenetics of Chronic Pain, Volume Nine, presents comprehensive information on the role of epigenetics in chronic pain sensitivity, providing a detailed, but accessible, view of the field from basic principles, to clinical application. Leading international researchers discuss essential mechanisms of chronic pain epigenetics, including the molecular processes of chromatin remodeling, histone modifications, and the microRNAs and noncoding RNAs involved in regulating genes tied to pain sensitivity. The influence of epigenetics in inflammatory, neuropathic, visceral and other pain models is examined, with data derived from epigenetic studies on peripheral and central mechanisms of pain sensitivity in animal models and clinical cases studies. The studies and case examples cited highlight therapeutic pathways of significance and next steps for researchers to develop epigenetic-based treatments for chronic pain. In recent years, epigenetic regulation of gene expression has been shown to play a central role in managing human pain sensitivity. Findings show that expression of many genes critical to increases or decreases in pain sensitivity are indeed regulated by DNA methylation and its enzymes, histone-involved chromatin remodeling, and noncoding RNAs, mainly microRNAs.
  table of contents: Epigenetic tools in chronic pain studies -- Epigenetic regulation of peripheral macrophages in neurpathic pain -- Emphasizing histone-related chromatin remodeling in the central nervous system of animal models of chronic pain -- Role of histone modifications in chronic pain development -- Role of DNA methylation in chronic pain -- Pain-induced chromatin modification s-- DNA methylation/demethylation homeostasis and various pain conditions -- Epigenetic modulation of visceral pain -- Noncoding RNAs are new players in chronic pain -- Epigenetics of chronic visceral nociception -- An overview of epigenetic correlates of human chronic pain conditions.
  note: edited by Guang Bai, Department of Neural and Pain Sciences, School of Dentistry, and Program in Neuroscience, University of Maryland, Baltimore, MD, United States, Ke Ren, Department of Neural and Pain Sciences, School of Dentistry, and Program in Neuroscience, University of Maryland, Baltimore, MD, United States.
  note: Includes bibliographical references and index.
  subject:
    topic: Chronic pain
  subject:
    topic: Epigenetics
  subject:
    topic: Chronic Pain
    topic: genetics
  subject:
    topic: Epigenesis, Genetic
  subject:
    topic: Epigenomics
  subject:
    topic: Douleur chronique
  subject:
    topic: Épigénétique
  subject:
    topic: MEDICAL
    topic: Pain Medicine
  subject:
    topic: Chronic pain
  subject:
    topic: Epigenetics
  classification: RB127.5.C48
  classification: 616/.0472
  classification: 2019 A-988
  classification: WL 704
  related item:
    identifier: (OCoLC)1040659271
  related item:
    title info:
      title: Translational epigenetics series ; v. 7
  identifier: 9780128140710
  identifier: 0128140712
  identifier: 9780128140703
  identifier: 0128140704
  identifier: 9780128140710 Ingram Content Group
  identifier: http://proxy.library.tamu.edu/login
  record info:
    record content source: N$T
    record creation date: 181101
    record change date: 20260327154038.0
    record identifier: in00005764083
    language of cataloging:
      language term: eng