http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
The Value of BCG and TNF in Autoimmune Diseases, Second Edition provides an overview on the current research related to TNF induction and the use of the BCG vaccine as a potential treatment approach to diverse forms of autoimmunity, allergies, infections and neurologic diseases. Since the initial conference (2013) and first edition of this book (2014), the field of BCG research has grown considerably. This new edition contains updates on MS and diabetes, and features at least eight additional chapters on new prevention and treatment trials in autoimmunity and allergy, along with a new understanding of the genetics of BCGs.- Brings a different perspective on treatment approaches for certain autoimmune conditions- Gives insight into the how the BCG vaccine impacts gene expression and the durability of the BCG vaccines in long lasting clinic effects- Discusses TNF induction, rather than anti-TNF, as a therapeutic pathway for autoimmunity treatment- Covers new topics, such as the Epigenetics of tuberculosis, BCG in neurological disease, BCG in early childhood and allergy, BCG in large prevention trials, Gene expression of BCG and re-methylation of genes, and more.
Chapter 1. BCG: its impact on tuberculosis and relevance to autoimmune disease -- Chapter 2. The potential of TNF induction from BCG for the treatment of Type 1 Diabetes -- Chapter 3. Bacille Calmette-Guerin (BCG) vaccine in neuroinflammation -- Chapter 4. Host epigenetic modifications in Mycobacterium tuberculosis infection: a boon or bane -- Chapter 5. Mycobacterium Bovis Bacille Calmette-Guerin vaccination: can biomarkers predict efficacy? -- Chapter 6. The heterologous effects of Bacillus Calmette-Guerin (BCG) vaccine and trained innate immunity -- Chapter 7. Nonspecific effects of neonatal Bacille Calmette-Guerin (BCG) vaccination -- from West African observations to a Danish randomized clinical trial -- Chapter 8. Epigenetic rewiring of monocytes in BCG vaccination -- Chapter 9. Mycobacteria, immunoregulation, and autoimmunity -- Chapter 10. mTORC1 links cellular metabolism and immune functions in Mycobacterium tuberculosis infection and BCG vaccination -- Chapter 11. The role of maternal priming and boosting for the nonspecific effects of BCG vaccine -- Index.
Includes bibliographical references and index.
London, United Kingdom ; San Diego, CA, United States : Academic Press, [2018]