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Antimicrobial peptides in gastrointestinal diseases
Antimicrobial peptides (AMPs), including cathelicidins and defensins are host defence peptides that carry out multiple roles in the gastrointestinal (GI) tract. Antimicrobial Peptides in Gastrointestinal Diseases presents knowledge about the physiological functions and pharmacological actions of AMPs in inflammation, cancer, and further infection of the GI tract. The book provides coverage from the basic research to clinical application for GI diseases. Current research and development of AMPs is presented, opening the way for further work on these peptides, not only in the context of GI diseases, but also for similar pathologies in other organs. AMPs are key to the regulation of human microbiome and second line defence in the GI mucosa, prevent colonization of pathogens and modulation of innate response to invading pathogens, and modify immunological reactions during inflammatory processes and oncogenic development in the GI mucosa. More importantly, AMPs possess diversified anti-microbial actions against various infectious diseases in the GI tract. With these physiological functions and pharmacological actions, AMPs have significant potential as therapeutic agents for the treatment of inflammation, cancer and further infection in the GI tract. Provides an overview of AMPs, particularly cathelicidin and defensin, in different diseasesCovers inflammation and ulcer repair in the stomach and colon and carcinogenesis in the GI tractPresents AMP information and knowledge in a concise mannerGives useful information on all aspects of AMPsPromotes research on AMPs and their development as drugs, from bench, to clinical application.
Front Cover; Antimicrobial Peptides in Gastrointestinal Diseases; Copyright; Contents; Contributors; General Introduction of Antimicrobial Peptides and Gastrointestinal Diseases; Chapter 1: Regulation of Cationic Antimicrobial Peptides Expression in the Digestive Tract; 1. Digestive Tract Microbiome as a Factor Regulating Expression of Cationic Antibacterial Peptides; 2. Factors Regulating Expression of AMPs and Molecular Mechanisms Governing This Process; 3. Regulation of AMPs Expression in Autoimmune Disorders Associated With the Gastrointestinal Tract
4. Stimulated Expression of AMPs in the Digestive Tract as a Potential New Method for Infection Treatment: A Great Altern ... 5. Conclusions; References; Chapter 2: Antimicrobial Peptides in the Host-Microbiota Homeostasis; 1. Background; 2. Characteristic of Microbiota; 2.1. Composition in the Skin Microbiome; 2.2. Composition in the Respiratory Tract Microbiome; 2.3. Composition in the Gastrointestinal Tract Microbiome; 3. Biological Function of Antimicrobial Peptides; 4. Antimicrobial Peptide as a Targeted Modulator on Human Microbiome; 5. Challenges and Future Avenues; References
Further ReadingChapter 3: The Roles of Antimicrobial Peptides in the Regulation of Gastrointestinal Microbiota and Innate Immunity; 1. A Brief Introduction to Gastrointestinal Antimicrobial Peptides; 2. The Utility of AMPs as IBD Biomarkers; 3. Bacterial-Derived Substances Activate Innate Mucosal Immunity Via Cathelicidin Expression; 4. The Roles of AMPs in Gastrointestinal Infection and Inflammation; 5. The Roles of AMPs in Obesity, Liver Steatosis, and Metabolic Syndromes; 6. Concluding Remarks; References; Chapter 4: Cathelicidin in Gastrointestinal Disorders; 1. Introduction
2. The Distribution and Functions of Cathelicidin in the GI Tract2.1. The Distribution of Cathelicidin in the GI Tract; 2.2. The Functions of Cathelicidin in the GI Tract; 2.2.1. Mechanism of Antimicrobial Action; 2.2.2. Preventing Lipopolysaccharide (Lps)-Induced Inflammation; 2.2.3. Modulatory Influences in Inflammation; 2.2.4. Clearance of Active Inflammatory Mediators; 2.3. Cathelicidin and Wound Healing; 2.3.1. Angiogenic Influences; 2.3.2. Mitogenic and Promigratory Influences; 3. The Role of Cathelicidin in H. pylori Infection, Gastric Cancer, and Mucosal Repair in the Stomach
3.1. Cathelicidin and H. pylori Infection3.2. Cathelicidin and Gastric Cancer; 3.3. Cathelicidin and Wound Repair in the Stomach; 4. The Role of Cathelicidin in Ulcerative Colitis and Colon Cancer; 4.1. General Introduction to Ulcerative Colitis; 4.2. Intestinal Microbiota and Ulcerative Colitis; 4.3. Cathelicidin and Ulcerative Colitis; 4.4. Cathelicidin and Colon Cancer; 5. Final Conclusion Using Cathelicidin as a Potential Therapeutic Agent for GI Disorders; References; Chapter 5: Antimicrobial Peptides as Potential Therapy for Gastrointestinal Cancers: Opportunities and Challenges
Includes bibliographical references and index.
London, United Kingdom : Academic Press, an imprint of Elsevier, 2018