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International review of cell and molecular biology
International Review of Cell and Molecular Biology. Volume 336 reviews and details current advances in cell and molecular biology. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics that are authored by prominent cell and molecular biologists. This updated volume includes specific chapters on Membrane trafficking in autophagy, Targeting the metabolism of leukemic cells, Autophagic flux in Alzheimer's disease, Transcriptional alterations associated with celiac disease, and the Regulation of antitumor immunity by IDO1, amongst other timely topics. The articles published in IRCMB have a high impact and an average cited half-life of 9 years. This great resource ranks high amongst scientific journals dealing with cell biology.
Intro; Title page; Table of Contents; Copyright; Contributors; Chapter One: Membrane Trafficking in Autophagy; Abstract; 1 Introduction; 2 Autophagy; 3 Membrane Trafficking; 4 Membrane Trafficking in Autophagosome Formation; 5 Autophagosome Maturation; 6 Autophagic Lysosome Reformation; 7 Noncanonical Autophagy; 8 Concluding Remarks; Acknowledgments; Chapter Two: Altered Metabolism of Leukemic Cells: New Therapeutic Opportunity; Abstract; 1 Introduction; 2 Leukemia Classification; 3 Current Therapy; 4 Metabolism of Normal Hematopoietic vs Leukemic Cells; 5 Glucose Metabolism
6 Oxidative Phosphorylation7 Tricarboxylic Acid Cycle: Isocitrate Dehydrogenase; 8 Lipid Metabolism; 9 Amino Acid Metabolism; 10 Concluding Remarks; Acknowledgments; Chapter Three: Profiling Celiac Disease-Related Transcriptional Changes; Abstract; 1 Celiac Disease; 2 Microarray Studies; 3 RNA-Seq Studies; 4 miRNA Expression; 5 Disease Association and Function: Expression Quantitative Trait Loci; 6 CD Variants in Noncoding Regions; Chapter Four: Indoleamine 2,3-Dioxygenase and Its Therapeutic Inhibition in Cancer; Abstract; 1 Introduction; 2 IDO1 in Immune Escape From T Cell Immunity
3 IDO1 in Inflammatory Programming: MDSC Development and Metastasis4 IDO1 in Inflammatory Programming: Pathogenic Neovascularization and Metastasis; 5 IDO2 in B-Cell Inflamed States and Certain IDO1 Functions: Connections and Questions; 6 TDO in Inflammatory Programming: Immune Escape, Anoikis Resistance, and Metastasis; 7 Lead Clinical Agents: Indoximod, Epacadostat, and Navoximod; 8 Other IDO/TDO Inhibitor Clinical Candidates; Acknowledgments; Chapter Five: Loss of Nuclear Envelope Integrity in Aging and Disease; Abstract; 1 The Nuclear Envelope Safeguards Nuclear Compartmentalization
2 Nuclear Envelope Erosion Compromises Transport Selectivity3 Nuclear Envelope Shedding Bypasses NPC Control; 4 Nuclear Envelope Rupture Triggers Abhorrent Nucleocytoplasmic Exchange; 5 Conclusion; Acknowledgment; Chapter Six: Mechanisms of Cortical Differentiation; Abstract; 1 Introduction; 2 A Primer on Neocortical Anatomy; 3 Early Neocortical Development; 4 Control of Neocortical Neurogenesis; 5 Control of Neocortical Gliogenesis; 6 Conclusions and Future Perspectives; Acknowledgments
Chapter Seven: New Insights Into Autophagy Dysfunction Related to Amyloid Beta Toxicity and Neuropathology in Alzheimer's DiseaseAbstract; 1 Introduction; 2 Autophagy and Its Machinery; 3 AÎ² Biogenesis and AD-Related Toxicity; 4 Autophagy Dynamics and AD Pathogenesis; 5 APP and the Autophagosome: Site of Clearance and Site of Production; 6 AÎ² Clearance and the Role of Autophagy in AÎ² Homeostasis; 7 The Protein Signature of Autophagic Failure in AD; 8 Autophagy Control: Therapeutic Interventions in AD; 9 Summary and Future Directions; Acknowledgments
International Review of Cell and Molecular Biology ; Volume 336