http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
1 online resource (381 pages) : color illustrations, tables.
Epigenetic Mechanisms in Cancer provides a comprehensive analysis of epigenetic signatures that govern disease development, progression and metastasis. Epigenetic signatures dictating tumor etiologies present an opportunity for biomarker identification which has broad potential for improving diagnosis, prognosis, prediction, and risk assessment.ïÅ½ This volumes offer a unique evaluation of signature differences in of childhood, sex-specific and race-specific cancers, and in doing so broadly illuminates the scope of epigenetic biomarkers in clinical environments.ïÅ½ Chapters detail the major epigenetic process in humans consisting of DNA methylation, histone modifications and microRNAs (miRNAs) involved in the initiation, progression and metastasis of tumors. Also delineated are recent technologies such as next generation sequencing that are used to identify epigenetic profiles (primarily methylation analysis) in samples (normal, benign and cancerous) and which are highly important to the analysis of epigenetic outcomes.
""Front Cover""; ""Epigenetic Mechanisms in Cancer""; ""Translational Epigenetics Series""; ""Epigenetic Mechanisms in Cancer""; ""Copyright""; ""Contents""; ""List of Contributors""; ""1 -- Epigenetic Dysregulation in Pediatric Leukemia""; ""1. INTRODUCTION""; ""2. DNA METHYLATION""; ""2.1 Role of DNA Methylation in Hematopoiesis""; ""2.2 Role in Leukemogenesis""; ""3. HISTONE MODIFICATION""; ""3.1 Role in Hematopoiesis""; ""3.2 Role in Leukemogenesis""; ""4. MICRORNA ALTERATIONS""; ""4.1 Role in Hematopoiesis""; ""4.2 Role in Leukemogenesis""
""5. THERAPEUTIC IMPLICATIONS AND FUTURE DIRECTIONS""""6. CONCLUSION""; ""Acknowledgments""; ""References""; ""2 -- Role of Epigenetics in Testicular Cancer""; ""1. INTRODUCTION""; ""2. TESTICULAR CANCER""; ""2.1 Etiology of the Testicular Germ Cell Tumors""; ""2.1.1 The Testicular Dysgenesis Syndrome""; ""2.1.2 Origin of the Testicular Germ Cell Cancer""; ""2.1.3 The Steroids Receptors""; ""3. EPIGENETIC PROCESSES: FROM NORMAL SPERMATOGENESIS TO TESTICULAR GERM CELL TUMORS""; ""3.1 The Epigenome of Germ Cells and Cancer""; ""3.1.1 DNA Methylation""
""3.1.1.1 DNA Methylation and Testicular Cancer""""3.1.2 Histones Modifications""; ""3.1.2.1 Histone Modifications and Testicular Cancers""; ""3.1.3 Noncoding RNA""; ""3.1.3.1 Noncoding RNA and Testicular Cancers""; ""3.1.4 Repression of Transposable Elements""; ""3.1.4.1 Retrotransponsons and Testicular Cancers""; ""4. THERAPY ISSUES: EPIGENETIC INFLUENCE AND RESISTANCE TO TREATMENT""; ""5. CONCLUSION""; ""List of Acronyms and Abbreviations""; ""Glossary""; ""References""; ""Further Reading""; ""3 -- Changes in the Epigenetic Landscape of Prostate Cancer""; ""1. INTRODUCTION""
""2. EPIGENETICS OF THE BIOLOGY OF THE PROSTATE""""2.1 Physiology of the Prostate""; ""2.2 Racial Differences in Prostate Cancer""; ""3. EPIGENETIC CHANGES IN PROSTATE CANCER""; ""3.1 Prostate Atrophy and Other Early Changes in Prostate Cancer""; ""3.2 Epigenetic Signatures of Prostate Cancer and NGS Technology""; ""3.3 Hormone-Refractory Cancers""; ""4. EPIGENETIC THERAPEUTICS""; ""4.1 Clinical Trials""; ""4.2 Commentary""; ""5. SUMMARY""; ""List of Acronyms and Abbreviations""; ""Glossary""; ""References""; ""4 -- The Genetics and Epigenetics of Colorectal Cancer Health Disparity""
""1. INTRODUCTION""""2. COLORECTAL CANCER TYPES""; ""3. COLORECTAL CANCER GENE-BASED DISPARITY""; ""3.1 P53""; ""3.2 Adenomatous Polyposis Coli Gene (APC)""; ""3.3 Multidrug Resistance 1 (MDR1)""; ""3.4 MutL Homolog1 (MHL1)""; ""4. EPIGENETIC MODIFICATIONS AND COLORECTAL CANCER""; ""4.1 DNA Methylation""; ""4.2 Histone Modifications""; ""4.3 MicroRNAs""; ""5. BIOMARKERS OF COLORECTAL CANCER DIAGNOSIS AND PROGNOSIS""; ""6. CONCLUSION""; ""LIST OF ABBREVIATIONS""; ""Acknowledgments""; ""References""; ""5 -- Genetic and Epigenetic Modifications in Pancreatic Cancer""; ""1. INTRODUCTION""