http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
Bioactive Polysaccharides offers a comprehensive review of the structures and bioactivities of bioactive polysaccharides isolated from traditional herbs, fungi, and seaweeds. It describes and discusses specific topics based on the authors' rich experience, including extraction technologies, practical techniques required for purification and fractionation, strategies and skills for elucidating the fine structures, in-vitro and in-vivo protocols, and methodologies for evaluating the specific bioactivities, including immune-modulating activities, anti-cancer activities, anti-oxidant activities, and others. This unique book also discusses partial structure-functionality (bioactivities) relationships based on conformational studies. This comprehensive work can be used as a handbook to explore potential applications in foods, pharmaceuticals, and nutraceutical areas for commercial interests.
Front Cover -- Bioactive Polysaccharides -- Copyright Page -- Contents -- Preface -- 1 Introduction -- 1.1 Definition of Polysaccharides and Their Research History -- 1.2 Overview of the Structure of Polysaccharide, and Structural Diversity -- 1.3 Overview on Bioactivities -- 1.3.1 Anticancer -- 1.3.2 Immunoregulation -- 1.3.3 Antidiabetics and Kidney Repair -- 1.3.4 Antioxidant -- 1.3.5 Antiinflammatory -- 1.3.6 Other -- 1.4 The Structureâ#x88;#x92;Bioactivity Relationship of Polysaccharides -- 1.4.1 Viscosity -- 1.4.2 Molecular Weight -- 1.4.3 Conformation
1.4.4 Substituent Group1.4.4.1 Sulfate Group -- 1.4.4.2 Carboxymethyl Group -- 1.4.4.3 Other Substitution Groups -- 1.5 Perspectives -- References -- 2 Methodologies for Studying Bioactive Polysaccharides -- 2.1 Isolation, Purification, and Characterization -- 2.2 Structural Analysis -- 2.2.1 Chemical Methods -- 2.2.1.1 Methanolysis -- 2.2.1.2 Acetolysis -- 2.2.1.3 Periodate Oxidation and Smith Degradation -- 2.2.1.4 Methylation Analysis -- 2.2.2 Instrumental Methods -- 2.2.2.1 UV-Vis Spectrophotometry and FTIR Spectroscopy
2.2.2.2 Chromatography and Mass Spectroscopy2.2.2.2.1 GC and HPLC -- 2.2.2.2.2 Mass Spectroscopy -- 2.2.2.2.3 FAB-MS -- 2.2.2.2.4 ESI-MS -- 2.2.2.2.5 MALDI-TOF -- 2.2.2.3 NMR Spectroscopy -- 2.2.2.3.1 Liquid-State NMR -- 2.2.2.3.2 Solid-State NMR -- 2.2.3 Biological Methods -- 2.3 Conformations -- 2.3.1 Light Scattering -- 2.3.2 Molecular Modeling -- 2.3.2.1 Force Fields -- 2.3.2.2 Minimization of Molecules -- 2.4 Animal Studies and Clinical Trials -- 2.4.1 Animal Models -- 2.4.2 Clinical Trials -- 2.4.2.1 Tissue Engineering
2.4.2.2 Wound Healing and Wound Dressing2.4.2.3 Drug Delivery and Controlled Release -- 2.4.2.4 Treatment of Cancer -- 2.5 Cell Culture: Action of Mechanismâ#x88;#x92;Polysaccharideâ#x88;#x92;Receptors Interactions -- 2.5.1 Natural Killer Group 2D -- 2.5.2 TGF-Î² Receptors -- 2.5.3 Toll-Like Receptor 4 -- 2.5.4 Toll-Like Receptor 2 -- 2.5.5 CD14 -- 2.5.6 Dectin-1 -- 2.5.7 Dectin-2 -- 2.5.8 The Mannose Receptor -- 2.5.9 Scavenger Receptors -- 2.5.10 CD19 and CD79 -- 2.5.11 Complement Receptor 3 (CR3) -- 2.5.12 Membrane Immunoglobulins
2.5.13 Receptor Protein 105/Myeloid Differentiation-1References -- 3 Beta-Glucans and Their Derivatives -- 3.1 Sources -- 3.1.1 Beta-Glucan From Fungi -- 3.1.2 Beta-Glucan From Bacteria -- 3.1.3 Beta-Glucan From Plants and Algae -- 3.2 Preparation, Extraction, and Purification -- 3.2.1 Hot-Water Extraction -- 3.2.2 Ultrasound-Assisted Extraction and Microwave-Assisted Extraction -- 3.2.3 Purification of Beta-Glucan -- 3.3 Structural Features -- 3.4 Molecular Characteristics -- 3.5 Bioactivities -- 3.5.1 Immune-Enhancement and Antitumor Effects
Shaoping Nie, Steve W. Cui, Mingyong Xie.
Includes bibliographical references and index.