http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
Research in the Biomedical Sciences: Transparent and Reproducible documents the widespread concerns related to reproducibility in biomedical research and provides a best practices guide to effective and transparent hypothesis generation, experimental design, reagent standardization (including validation and authentication), statistical analysis, and data reporting. The book addresses issues in the perceived value of the existing peer review process and calls for the need for improved transparency in data reporting. It reflects new guidelines for publication that include manuscript checklists, replication/reproducibility initiatives, and the potential consequences for the biomedical research community and societal health and well-being if training, mentoring, and funding of new generations of researchers and incentives for publications are not improved. This book offers real world examples, insights, and solutions to provide a thought-provoking and timely resource for all those learning about, or engaged in, performing and supervising research across the biomedical sciences.
Cover -- Title Page -- Copyright Page -- Contents -- List of Contributors -- Preface -- References -- Chapter 1 -- Reproducibility in Biomedical Research -- 1.1 -- Introduction -- 1.2 -- Defining Reproducibility -- 1.2.1 -- A New Lexicon for Reproducibility -- 1.2.1.1 -- Methods Reproducibility -- 1.2.1.2 -- Results Reproducibility -- 1.2.1.3 -- Inferential Reproducibility -- 1.2.1.4 -- Bayesian Paradigms in Reproducibility -- 1.3 -- Discipline Specific Terminology in the Biomedical Sciences?
1.4 -- Experimental Factors in Addition to Statistics That Affect Reproducibility1.4.1 -- Unknown Unknowns Affecting Reproducibility -- 1.4.1.1 -- The Crabbe Mouse Study -- 1.4.1.2 -- Reproducibility Confounds in RNA Interference -- 1.4.1.3 -- Caenorhabditis Lifespan -- 1.4.2 -- Known Unknowns: Tacit Expertize -- 1.4.3 -- Diminishing Effects: Regression to the Mean -- 1.4.4 -- Overinterpretation of Effects on Secondary Endpoints in Studies -- 1.5 -- The Impact of the Internet on the Evolution of Research Practicesâ#x80;#x94;Databases and Third Party Analyses -- 1.5.1 -- Data Input
1.5.2 -- Data Curation1.5.3 -- Cross-Database Integration -- 1.5.4 -- Analytical Tools -- 1.6 -- The Reproducibility Problem -- 1.6.1 -- Factors Contributing to the Reproducibility Problem -- 1.6.2 -- Human Contributions to the Reproducibility Problem -- 1.6.2.1 -- Litigation in Basic Biomedical Research -- 1.6.3 -- The Impact of the Internet on Publishing and Disseminating Information -- 1.6.3.1 -- High and Low Profile Journals -- 1.7 -- The Literature on Reproducibility in Biomedical Research -- 1.7.1 -- An Age-Old Concern -- 1.7.2 -- Concerns in the 21st Century
1.7.3 -- Reproducibility in the 21st Century: Origins, Scope and Momentum1.7.3.1 -- Why Most Published Research Findings are False -- 1.7.3.2 -- Believe it or not: How Much can we Rely on Published Data on Potential Drug Targets? -- 1.7.3.3 -- Drug Development: Raise Standards for Preclinical Cancer Research -- 1.7.3.4 -- Reproducibility: An Academic Viewpoint -- 1.7.3.5 -- Reproducibility in the Psychological Sciences -- 1.7.3.6 -- Researcher Awareness of Fraud -- 1.8 -- Is There a Reproducibility Crisis? -- 1.9 -- Trouble at the Laboratory? -- 1.10 -- Retractions
1.10.1 -- RetractionWatch1.10.2 -- Continued Citation of Retracted Publications -- 1.10.3 -- The Spectrum of Irreproducibility -- 1.10.4 -- Research Misconduct -- 1.10.5 -- Fraud -- 1.10.6 -- Notable Examples of Fraudâ#x80;#x94;Biomedical Researchers Behaving Badly -- 1.10.6.1 -- MMR Vaccine: Andrew Wakefieldâ#x80;#x94;Royal Free Hospital -- 1.10.6.2 -- Embryonic Stem Cells: Hwang Woo-Sukâ#x80;#x94;Seoul National University -- 1.10.6.3 -- Environment and Human Behavior: Diederik Stapelâ#x80;#x94;Tilburg University
""1.10.6.4 -- Stimulus-Triggered Acquisition of Pluripotency (STAP): Haruko Obokataâ#x80;#x94;RIKEN Institute""
edited by Michael Williams, Michael J. Curtis, Kevin Mullane.
Includes bibliographical references and index.