Cover Image

Advances in virus research Volume 98 /

Bibliographic Details
Corporate Author: ScienceDirect (Online service)
Other Authors: Kielian, Margaret C., 1952- (Editor), Mettenleiter, Thomas C. (Editor), Roossinck, Marilyn J. (Editor)
Format: eBook
Language:English
Published: Cambridge, MA : Academic Press, 2017.
Series:Advances in Virus Research v. 98
Subjects:
Virology.
Viruses.
Virology
Viruses
Virologie.
Virus.
Electronic books.
Online Access:Connect to the full text of this electronic book
Table of Contents:
  • Front Cover
  • Advances in Virus Research
  • Copyright
  • Contents
  • Contributors
  • Chapter One: Zoonotic Potential of Emerging Paramyxoviruses: Knowns and Unknowns
  • 1. Introduction
  • 2. Known Highly Lethal Emergent Paramyxoviruses: Nipah Virus and Hendra Virus
  • 2.1. Hendra Virus
  • 2.2. Nipah Virus
  • 2.3. Broad Geographic Distribution of Potentially Zoonotic Henipaviruses
  • 3. Unknown Zoonotic Potential of Paramyxoviruses
  • 3.1. Diversity of Novel Enzootic Paramyxoviruses
  • 3.2. Human Infection by Zoonotic Rubula-Like Viruses
  • 3.3. Zoonotic Transmission of Morbilliviruses
  • 4. Ecological Factors Driving Zoonotic Paramyxovirus Emergence
  • 4.1. Viral Prevalence and Diversity in Reservoir Hosts
  • 4.2. Frequency and Nature of Human-Animal Contacts
  • 4.3. Known Risk Factors: Hendra Virus and Nipah Virus
  • 4.4. Observed Trends With Unknown Driving Factors
  • 5. Virus-Host Molecular Interactions Affecting Paramyxovirus Emergence
  • 5.1. Successful Emergence Requires Host-Specific Interactions
  • 5.1.1. Effects of Receptor Specificity on Species and Tissue Tropism
  • 5.1.2. Use of SA as a Paramyxovirus Receptor
  • 5.1.3. Paramyxoviruses That Use Protein-Based Receptors
  • 5.1.4. Contribution of Host Conservation of Paramyxovirus Receptors to Spillover Risk
  • 5.1.5. Postentry Essential Host Factors That Are Species-Specific Are Not Yet Known
  • 5.1.6. Antagonism of Innate Immune Responses Is Known to Be Key to Successful Infection
  • 5.2. Unknown Connection Between Emergence and Pathogenicity
  • 5.3. Preexisting Immunity May Restrict Emergence
  • 6. Summary
  • Acknowledgments
  • References
  • Chapter Two: Metabolomics: Strategies to Define the Role of Metabolism in Virus Infection and Pathogenesis
  • 1. Introduction
  • 2. Metabolomics Analytical Strategy and Study Design
  • 2.1. Instruments and Analytical Methods for Metabolomics.
  • 2.2. Strategies for Statistical and Pathway Analysis
  • 2.3. Metabolic Pathway Interrogation, Validation, and Hypothesis Testing
  • 3. Using Metabolomics to Characterize Viral Infections
  • 3.1. Human Immunodeficiency Virus
  • 3.1.1. Early Application of Metabolomics to HIV/SIV
  • 3.1.2. Profiling Human Body Fluids
  • 3.1.3. Cell Culture Studies
  • 3.2. Hepatitis B Virus
  • 3.3. Hepatitis C Virus
  • 3.4. Influenza
  • 3.5. Dengue Virus
  • 3.6. Herpesviruses
  • 4. Metabolomics to Discover Target Networks for Broad Spectrum Antivirals
  • 5. Conclusions and Future Trends
  • References
  • Chapter Three: The Envelope Proteins of the Bunyavirales
  • 1. Introduction
  • 2. Bunyavirus Entry Into Cells
  • 3. Bunyavirus Gc Is a Class II Fusion Protein
  • 3.1. Phlebovirus Gc
  • 3.2. Hantavirus Gc (hGc)
  • 4. The Target Membrane-Interacting Region
  • 5. pH-Sensing Mechanisms
  • 6. Lipid Sensing
  • 7. The Stem Region
  • 8. Newly Identified pGc-Like Envelope Proteins
  • 9. Projections for Gc From Other Members of the Bunyavirales Order
  • 10. Hantavirus Gn Is Homologous to Alphavirus E2
  • 11. Discussion
  • References
  • Chapter Four: Insect-Specific Viruses: A Historical Overview and Recent Developments
  • 1. Introduction
  • 2. Background
  • 2.1. Discovery and Brief History
  • 2.2. Evolution of ISVs
  • 2.3. Maintenance in Nature
  • 2.4. Impact of ISVs on Experimental Studies-In Vitro and Lab Colonies
  • 3. Biological Characteristics of Value
  • 3.1. Superinfection Exclusion
  • 3.2. Host Restriction
  • 4. Specific Viral Families
  • 4.1. Flaviviridae
  • 4.1.1. Cell Fusing Agent Virus
  • 4.1.2. Culex flavivirus
  • 4.1.3. Kamiti River Virus
  • 4.1.4. Aedes flavivirus
  • 4.2. Reoviridae
  • 4.2.1. Fako Virus
  • 4.3. Togaviridae
  • 4.3.1. Eilat Virus
  • 4.4. Bunyaviridae
  • 4.4.1. Badu Virus
  • 4.5. Mesoniviridae
  • 4.6. Negeviruses.
  • 5. Conclusions and Future Perspectives
  • 5.1. The Use of ISVs as a Tool for Biological Control
  • 5.2. Vaccine and Diagnostic Applications of ISVs
  • Acknowledgments
  • References
  • Back Cover.