rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Advances in nanomedicine for the delivery of therapeutic nucleic acids
  name:
    name part: Nimesh, Surendra
    role:
      role term: editor.
  name:
    name part: Chan, Ramesh
    role:
      role term: editor.
  name:
    name part: Gupta, Nidhi
    role:
      role term: editor.
  name:
    name part: ScienceDirect (Online service)
  type of resource: text
  genre: bibliography
  genre: Electronic books.
  genre: Internet Resources.
  origin info:
    place:
      place term: enk
    date issued: 2017
    copyright date: 2017
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource.
  abstract: Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids addresses several issues related to safe and effective delivery of nucleic acids (NAs)ïÅ½using nanoparticles. A further emphasis would be laid on the mechanism of delivery of NAs, the barriers encountered and the strategies adapted to combat them. An exhaustive account of the advantages as well shortcomings of all the delivery vectors being employed in delivery of various NAs will be provided. On final note the regulatory aspects of nanoparticles mediated NA would be discussed, with focus on their clinical relevance.ïÅ½ The design and development of nucleic acid-based therapeutics for the treatment of diseases arising from genetic abnormalities has made significant progress over the past few years. NAs have been widely explored for the treatment of cancer and infectious diseases or to block cell proliferation and thereby caused diseases. Advances in synthetic oligonucleotide chemistry resulted in synthesis of NAs that are relatively stable in in vivo environments. However, cellular targeting and intracellular delivery of NAs still remains a challenge. Further development of NA-based therapeutics depends on the progress of safe and effective carriers for systemic administration. Nanomedicine has facilitated availability of vectors with diminished cytotoxicity and enhanced efficacy which are rapidly emerging as systems of choice. These vectors protect NAs from enzymatic degradation by forming condensed complexes along with targeted tissue and cellular delivery. During the past few years, a myriad reports have appeared reporting delivery of NAs mediated by nanoparticles. This book will provide an overview of nanoparticles being employed in the in vitro and in vivo delivery of therapeutically relevant NAs likeïÅ½DNA, siRNA, LNA, PNA, etc.
  table of contents: 1. Nanomedicine for delivery of therapeutic molecules -- 2. Nanoparticles as nucleic acid delivery vectors -- 3. Methods for charactericzation of nanoparticles -- 4. Nanoparticles for DNA delivery -- 5. Nanoparticles for siRNA-mediated gene silencing -- 6. Nanoparticles for locked nucleic acid delivery -- 7. Nanoparticles for ribozymes delivery -- 8. Nanoparticles for DNAzymes delivery -- 9. Pharmacokinetics and biodistribution of the nanoparticles -- 10. Nanotoxicology: evaluation of toxicity potential of nanoparticles -- 11. Regulatory aspects of nanoparticulate mediated nucleic acid delivery systems -- 12. Clinical studies and future prospects -- Index.
  note: edited by Surendra Nimesh, Ramesh Chandra, Nidhi Gupta.
  note: Includes bibliographical references and index.
  subject:
    topic: Nanomedicine
  subject:
    topic: Nucleic acids
    topic: Treatment
  subject:
    topic: Nucleic Acids
    topic: therapeutic use
  subject:
    topic: Nanoparticles
    topic: therapeutic use
  subject:
    topic: Nanomedicine
  subject:
    topic: Nanomédecine
  subject:
    topic: HEALTH & FITNESS
    topic: Holism
  subject:
    topic: HEALTH & FITNESS
    topic: Reference
  subject:
    topic: MEDICAL
    topic: Alternative Medicine
  subject:
    topic: MEDICAL
    topic: Atlases
  subject:
    topic: MEDICAL
    topic: Essays
  subject:
    topic: MEDICAL
    topic: Family & General Practice
  subject:
    topic: MEDICAL
    topic: Holistic Medicine
  subject:
    topic: MEDICAL
    topic: Osteopathy
  subject:
    topic: Nanomedicine
  classification: R857.N34
  classification: 610.28
  classification: QT 36.5
  related item:
    title info:
      title: Advances in nanomedicine for the delivery of therapeutic nucleic acids
    origin info:
      publisher: Duxford : Woodhead Publishing, [2017]
    identifier: (OCoLC)964294012
  related item:
    title info:
      title: Woodhead Publishing series in biomedicine
  identifier: 9780081005637
  identifier: 0081005636
  identifier: 9780081005576
  identifier: 0081005571
  identifier: 2017449100
  identifier: 9780081005637 Ingram Content Group
  identifier: http://proxy.library.tamu.edu/login
  record info:
    record content source: N$T
    record creation date: 170407
    record change date: 20260327151820.5
    record identifier: in00005761706
    language of cataloging:
      language term: eng