rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Advances in immunology
    part number: Volume 133
  name:
    name part: Alt, Frederick W.
    role:
      role term: editor.
  name:
    name part: ScienceDirect (Online service)
  type of resource: text
  genre: bibliography
  genre: Electronic books.
  origin info:
    place:
      place term: mau
    date issued: 2017
    edition: First edition.
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource
  abstract: Advances in Immunology, a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.
  table of contents: Front Cover; Advances in Immunology; Copyright; Contents; Contributors; Chapter One: Macrophages and Mitochondria: A Critical Interplay Between Metabolism, Signaling, and the Functional Activity; 1. Introduction; 2. Mitochondrial Metabolism Governs Macrophage Activation State; 2.1. Metabolic Reprogramming in Proinflammatory Macrophages; 2.2. Metabolic Profile in IL-4-Activated Macrophages; 3. Mitochondrial ROS in Innate Immune Responses; 3.1. mROS Are Crucial Components of Inflammatory Signaling Pathways; 3.2. TLR Signaling Upregulates mROS Production
  table of contents: 3.3.3. Recruiting AID Activity to the lg Locus Is a Team Effort 3.3.4. Contribution of RNA Processing to AID Targeting; 3.4. Phosphorylation Focuses AID Activity to the Ig Locus; 4. AID Initiates a DNA Repair Cascade; 4.1. Detecting Uracil; 4.2. The UNG and Base Excision Repair Arm; 4.3. The MutSa-Initiated Arm; 4.4. Interactions Between BER and MMR During Antibody Diversification; 4.5. DNA Nicks and Breaks; 4.6. Repairing the Breaks; 5. Postdeamination Roles of AID; 6. Perspectives; Acknowledgments; References
  table of contents: 4. Mitochondrial-Mediated Antiviral Immunity4.1. RIG-I-Like Receptors; 4.2. Mitochondrial Antiviral Signaling; 4.3. Proteins That Regulate MAVS Signaling; 4.4. Mitochondrial Dynamics Regulate Antiviral Immunity; 4.5. ROS Regulation of Antiviral Signaling; 5. Inflammasome Activation and Mitochondria; 5.1. The Mitochondrion Is a Scaffold for Inflammasome Activation; 5.2. Mitochondrial Signals in Inflammasome Activation; 5.3. Mitophagy Restrains Inflammasome Activation; 6. Concluding Remarks; Acknowledgments; References
  table of contents: Chapter Two: Molecular Mechanisms of Somatic Hypermutation and Class Switch Recombination1. Antibody Diversification During the Humoral Response; 2. Molecular Mechanisms of SHM and CSR; 2.1. Overview; 2.2. Relevance for Humoral Immunity; 3. DNA Deamination at the Igs; 3.1. Activation-Induced Deaminase; 3.2. Molecular Regulation of AID Activity; 3.2.1. Biochemical Activity of AID; 3.2.2. Limiting the Levels of AID in the Nucleus; 3.3. Targeting AID to the Ig Loci; 3.3.1. AID Piggybacks on Transcription to Access the DNA; 3.3.2. The Ig Loci Contribute to AID Activity
  table of contents: Chapter Three: Emerging Major Histocompatibility Complex Class I-Related Functions of NLRC51. Background; 2. Lessons From CIITA; 2.1. CIITA: The Master Transcriptional Regulator of MHC Class II Genes; 2.2. Transcriptional Regulation of CIITA; 2.3. Transcriptional Regulation by CIITA; 2.4. Transcriptional Targets of CIITA; 3. NLRC5 and Its Role in Regulating MHC Class I Levels; 3.1. Complex Transcriptional Regulation of MHC Class I Genes; 3.2. NLRC5: A Transcriptional Regulator of MHC Class I Genes; 3.3. NLRC5 vs CIITA: Similarities and Differences
  note: edited by Frederick W. Alt.
  note: Includes bibliographical references and index.
  subject:
    topic: Immunology
  subject:
    topic: Allergy and Immunology
  subject:
    topic: Immunologie
  subject:
    topic: HEALTH & FITNESS
    topic: Diseases
    topic: General
  subject:
    topic: MEDICAL
    topic: Clinical Medicine
  subject:
    topic: MEDICAL
    topic: Diseases
  subject:
    topic: MEDICAL
    topic: Evidence-Based Medicine
  subject:
    topic: MEDICAL
    topic: Internal Medicine
  subject:
    topic: Immunology
  classification: QR181
  classification: 616.07/9
  related item:
    identifier: (OCoLC)957680867
  related item:
    title info:
      title: Advances in immunology ; v. 133
  identifier: 9780128124109
  identifier: 0128124105
  identifier: 0128124091
  identifier: 9780128124093
  identifier: http://proxy.library.tamu.edu/login
  record info:
    record content source: N$T
    record creation date: 170222
    record change date: 20260327151631.7
    record identifier: in00005761674
    language of cataloging:
      language term: eng