Molecular and cellular basis of metastasis : road to therapy /
"This thematic issue of Advances in Cancer Research contains eight chapters written by experts in specific areas of cancer biology ... This volume will be of use to both basic scientists and clinicians interested in an up-to-date overview of this pathological process that is a major determinant...
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| Other Authors: | , |
| Format: | eBook |
| Language: | English |
| Language Notes: | Text in English. |
| Published: |
Cambridge, MA :
Elsevier Academic Press,
2016.
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| Series: | Advances in Cancer Research ;
v. 132. |
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- Front Cover; Molecular and Cellular Basis of Metastasis: Road to Therapy; Copyright; Contents; Contributors; Preface; Chapter One: Detecting Tumor Metastases: The Road to Therapy Starts Here; 1. Introduction; 2. Preclinical In Vitro and In Vivo Models of Metastasis; 2.1. In Vitro Models; 2.2. In Vivo Models; 3. Approaches Currently Used to Detect Metastatic Lesions (on a Preclinical Level); 3.1. Lab Tests/Histopathology; 3.2. Noninvasive Blood Tests; 3.3. Small Animal Imaging; 3.4. Molecular-Genetic Imaging (Promoter-Based Protocols); 3.5. Circulating Tumor Cells
- 4. Approaches Used to Detect Metastatic Lesions (on a Clinical Level)4.1. Biomarkers for Metastasis; 4.2. Imaging Procedures; 4.3. Circulating Tumor Cells; 5. Metastasis Detection/Therapy: Combining Imaging with Therapy (Theranostics); 6. Challenges Faced in Detecting Metastatic Cells; 7. Conclusions and Future Directions; Acknowledgments; References; Chapter Two: The Relationship Between Dormant Cancer Cells and Their Microenvironment; 1. Introduction; 2. Models to Study Tumor Cell Dormancy; 3. Intrinsic and Extrinsic Signals Converge to Induce Tumor Cell Dormancy
- 4. Cooperative Extrinsic Signals Induce Dormancy Within the Bone Microenvironment5. Endosteal and Perivascular Niches Support Cancer Cell Dormancy; 6. Reactivation from Dormancy; 7. The Immune System and Dormancy; 8. Summary and Outlook; References; Chapter Three: Defining the Influence of Germline Variation on Metastasis Using Systems Genetics Approaches; 1. Introduction; 2. Hereditary Factors Associated with Cancer Aggressiveness and Metastasis in Human Populations; 2.1. Epidemiological Analysis; 2.2. Genetic Analysis Human Cohorts
- 3. Systems Genetics Approaches to Identify Hereditary Modifiers of Metastasis3.1. Breast Cancer; 3.2. Prostate Cancer; 3.3. Melanoma; 4. Conclusions; Acknowledgments; References; Chapter Four: Breast Cancer Metastasis Suppressor 1 (BRMS1): Robust Biological and Pathological Data, But Still Enigmatic ...; Concluding Thoughts; Acknowledgments; References; Chapter Five: Immune Regulation of the Metastatic Process: Implications for Therapy; 1. Introduction; 2. Key Players; 2.1. Monocytes; 2.2. Macrophages; 2.3. Neutrophils; 2.4. T Lymphocytes; 2.5. Natural Killer Cells
- 3. Invasion and Intravasation3.1. Macrophages; 3.2. Neutrophils; 3.3. T Lymphocytes; 4. Survival and Extravasation; 4.1. Monocytes; 4.2. Neutrophils; 4.3. T Lymphocytes; 4.4. NK Cells; 5. Ectopic Growth; 5.1. Macrophages; 5.2. Neutrophils; 5.3. T Lymphocytes; 5.4. NK Cells; 6. Therapeutic Implications; Acknowledgments; References; Chapter Six: MicroRNA and Metastasis; 1. MicroRNAs; 1.1. Noncoding RNAs and the Discovery of MicroRNAs; 1.2. miRNA Biogenesis and Mechanisms of Action; 1.3. miRNA Functions; 2. miRNAs in Cancer; 2.1. Deregulated Expression of miRNAs in Cancer