rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Thresholds of genotoxic carcinogens
    sub title: from mechanisms to regulation
  name:
    name part: Nohmi, Takehiko
    role:
      role term: editor.
  name:
    name part: Fukushima, Shoji
    role:
      role term: editor.
  name:
    name part: ScienceDirect (Online service)
  type of resource: text
  genre: bibliography
  genre: Electronic books.
  origin info:
    place:
      place term: enk
    date issued: 2016
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource
  table of contents: Title page; Table of Contents; Copyright; List of Contributors; Preface; Chapter 1. Qualitative and Quantitative Assessments on Low-Dose Carcinogenicity of Genotoxic Hepatocarcinogens: Dose-Response for Key Events in Rat Hepatocarcinogenesis; Abstract; Introduction; Qualitative and Quantitative Analyses on Low-Dose Carcinogenicity of 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline in the Rat Liver; Qualitative and Quantitative Analyses on Low-Dose Hepatocarcinogenicity of 2-Amino-3-methylimidazo[4,5-f]quinoline in the Rat Liver.
  table of contents: Qualitative and Quantitative Analysis on Low-Dose Hepatocarcinogenicity of N-nitrosodiethylamine in the Rat LiverDiscussion; References; Chapter 2. Thresholds for Hepatocarcinogenicity of DNA-Reactive Compounds; Abstract; Introduction; Dose-Effect Studies of Initiation of Liver Carcinogenesis; Conclusions; Relevance to Humans; References; Chapter 3. Interaction of Low-Dose Radiation and Chemicals in Cancer Risk; Abstract; Epidemiological Analysis of Cancer Risk; Interaction of Radiation and Other Carcinogens; Data From Animal Experiments; Conclusion; Acknowledgments; References.
  table of contents: Chapter 4. Possible Mechanisms Underlying Genotoxic Thresholds: DNA Repair and Translesion DNA SynthesisAbstract; Introduction; Challenges in Identification of Genotoxicity of Chemicals; Possible Mechanisms Underlying Genotoxic Thresholds; Significance of DNA Repair Mechanisms in the Suppression of Mutagenesis and Tumorigenesis in Mammals; TLS as a Critical Factor for Mutagenesis; Future Perspectives; Acknowledgments; References; Chapter 5. DNA Repair and Its Influence on Points of Departure for Alkylating Agent Genotoxicity; Abstract; Introduction.
  table of contents: The Paradigm Shift in Response to Low Doses of Alkylating AgentsAlkylating Agent Mechanism of Action; DNA Repair of Alkyl Adducts: Potential Influences on PoDs; Mechanistic Evidence Supporting a PoD for EMS; Mechanistic Evidence Supporting a PoD for ENU; Mechanistic Evidence Supporting a PoD for MMS; Mechanistic Evidence Supporting a PoD for MNU; Concluding Remarks; References; Chapter 6. The Role of Endogenous Versus Exogenous DNA Damage in Risk Assessment; Abstract; Introduction; Aldehydes; Alkylating Agents; Oxidative Stress; Ionizing Radiation.
  table of contents: Quantifying Complex Dose-Response Relationships to Support Risk AssessmentsConclusion; References; Chapter 7. Thresholds of Toxicological Concern for Genotoxic Impurities in Pharmaceuticals; Abstract; Introduction; Genotoxic and Nongenotoxic Carcinogens; Thresholds of Chemical Genotoxicity; Risk Management for Genotoxic Carcinogens; Risk Assessment and Control of Genotoxic Impurities in Pharmaceuticals; Conclusion; References; Chapter 8. Practical Thresholds in the Derivation of Occupational Exposure Limits (OELs) for Carcinogens; Abstract; Introduction.
  note: edited by Takehiko Nohmi, Shoji Fukushima.
  note: Includes index.
  note: Includes bibliographical references at the end of each chapters and index.
  subject:
    topic: Genetic toxicology
  subject:
    topic: Carcinogenesis
  subject:
    topic: DNA damage
  subject:
    topic: Drugs
    topic: Dose-response relationship
  subject:
    topic: Mutagenicity testing
  subject:
    topic: Carcinogenesis
  subject:
    topic: Carcinogens
    topic: toxicity
  subject:
    topic: DNA Damage
  subject:
    topic: Dose-Response Relationship, Drug
  subject:
    topic: Mutagenicity Tests
  subject:
    topic: Toxicologie génétique
  subject:
    topic: Cancérogenèse
  subject:
    topic: ADN
    topic: Lésions
  subject:
    topic: Médicaments
    topic: Relations dose-effet
  subject:
    topic: Mutagénicité
  subject:
    topic: HEALTH & FITNESS
    topic: Diseases
    topic: General
  subject:
    topic: MEDICAL
    topic: Clinical Medicine
  subject:
    topic: MEDICAL
    topic: Diseases
  subject:
    topic: MEDICAL
    topic: Evidence-Based Medicine
  subject:
    topic: MEDICAL
    topic: Internal Medicine
  subject:
    topic: Mutagenicity testing
  subject:
    topic: Drugs
    topic: Dose-response relationship
  subject:
    topic: DNA damage
  subject:
    topic: Carcinogenesis
  subject:
    topic: Genetic toxicology
  classification: RA1224.3
  classification: 616/.042
  classification: 2016 G-894
  classification: QZ 203
  related item:
    title info:
      title: Thresholds of Genotoxic Carcinogens : From Mechanisms to Regulation
    name:
      name part: Nohmi, Takehiko.
    origin info:
      publisher: : Elsevier Science, ©2016
  identifier: 9780128018033
  identifier: 0128018038
  identifier: 9780128016633
  identifier: 0128016639
  identifier: 9780128018033 Ingram Content Group
  identifier: http://proxy.library.tamu.edu/login
  record info:
    record content source: N$T
    record creation date: 160525
    record change date: 20260327150430.5
    record identifier: in00005760450
    language of cataloging:
      language term: eng