http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
historical perspective on evidence-based immunology
A Historical Perspective on Evidence-Based Immunology focuses on the results of hypothesis-driven, controlled scientific experiments that have led to the current understanding of immunological principles. The text helps beginning students in biomedical disciplines understand the basis of immunologic knowledge, while also helping more advanced students gain further insights. The book serves as a crucial reference for researchers studying the evolution of ideas and scientific methods, including fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, the generation of diversity and mechanism of tolerance of T cells and B cells, the first cytokines, the concept of autoimmunity, the identification of NK cells as a unique cell type, the structure of antibody molecules and identification of Fab and Fc regions, and dendritic cells.
Front Cover; Dedication; A HISTORICAL PERSPECTIVE ON EVIDENCE-BASED IMMUNOLOGY; Copyright; Contents; Foreword; Glossary of Historical Terms; 1 -- Innate Host Defense Mechanisms and Adaptive Immun; INTRODUCTION; INNATE DEFENSE MECHANISMS; Anatomy; Cells of the Innate Host Defenses; Antimicrobial Molecules; Effector Mechanisms; Inflammation; Phagocytosis; Complement; NK Lymphocyte-mediated Cytotoxicity; Recognition of Pathogens; ADAPTIVE IMMUNE RESPONSES; Anatomy; Lymphocytes of the Adaptive Immune/ esponse; Effector Mechanisms; Recognition of Pathogens; CONCLUSION; References; TIME LINE.
2 -- Hallmarks of the Adaptive Immune ResponsesINTRODUCTION; IMMUNOLOGIC SPECIFICITY; Specificity of the Adaptive Immune Response to/ iological Pathogens; Specificity of the Response to Synthetic Pathogens; SELF-NON-SELF-DISCRIMINATION; IMMUNOLOGIC MEMORY; Early Anecdotal Evidence; Smallpox Vaccination Comes to Western Medicine; Development of Other Vaccines; Mechanisms to Explain Immunologic Memory; Duration of Immunologic Memory; Cell Proliferation in Immunologic Memory; CONCLUSION; References; TIME LINE; 3 -- Two Effector Mechanisms of the Adaptive Immune Response; INTRODUCTION; ANTIBODY.
Development of SerotherapyEhrlich's Side-Chain Theory of Antibody Formation; CELL-MEDIATED IMMUNITY; Transfer of Skin Hypersensitivity Reactions; Transfer of Graft Rejection; CONCLUSION; References; TIME LINE; 4 -- The Small Lymphocyte Is the Antigen Reactive Cell; INTRODUCTION; THE SMALL LYMPHOCYTE; PASSIVE TRANSFER EXPERIMENTS; MIGRATORY PATHWAYS OF SMALL LYMPHOCYTES; DEPLETION EXPERIMENTS; IMMUNOCOMPETENCE OF THORACIC DUCT LYMPHOCYTES; MORPHOLOGICAL CHANGES OF ACTIVATED SMALL/ YMPHOCYTES; CONCLUSION; References; TIME LINE; 5 -- Lymphocytes Transform into Plasma Cells and Produce Antibodies.
INTRODUCTIONCELLS AND ANTIBODIES; Composition of Antibodies; ANTIGENS AND ANTIBODIES IN/ YMPHOID ORGANS; LYMPHOCYTE-PLASMA CELL DEBATE; PASSIVE TRANSFER STUDIES; VISUALIZATION OF ANTIBODY-FORMING CELLS; Observations Using Immunofluorescent Stains; TRANSFORMATION OF SMALL LYMPHOCYTES INTO/ LASMA CELLS; CONCLUSION; References; TIME LINE; 6 -- The Clonal Selection Theory of Antibody Formation; INTRODUCTION; EARLY MODELS OF ANTIBODY FORMATION; CHALLENGES TO INSTRUCTION MODELS; PARADIGM SHIFT: FROM INSTRUCTION TO SELECTION; The Modified Enzyme Concept.
The Natural Selection Hypothesis of/ ntibody FormationTHE CLONAL SELECTION THEORY; An Attempt to Disprove the Clonal Selection Theory; Extension of the Clonal Selection Theory to/ Lymphocytes; CONCLUSION; References; TIME LINE; 7 -- Plasma Cells Produce Antibody of a Single Specificity; INTRODUCTION; SINGLE CELL EXPERIMENTS: DEVELOPMENT OF THE/ ICRODROP TECHNIQUE; IMMUNOFLUORESCENT STUDIES; ANTIGEN RECEPTORS ON B LYMPHOCYTES; Cell Surface Immunoglobulin and Secreted Antibody Possess the Same Specificity; MULTIPLE MYELOMA AND THE ONE CELL: ONE/ NTIBODY CONCEPT.
Includes bibliographical references and index.