rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Omic studies of neurodegenerative disease
    part number: Part A
  name:
    name part: Hurley, Michael J.
    role:
      role term: editor.
  name:
    name part: ScienceDirect (Online service)
  type of resource: text
  genre: Electronic books.
  origin info:
    place:
      place term: mau
    date issued: 2015
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource
  abstract: Omic Studies of Neurodegenerative Disease: Part B is part of a well-established international series on neuroscience that examines major areas of basic and clinical research, along with emerging and promising subfields. The book informs the reader on the current state of the studies used to evaluate the mechanisms, causes, and treatment of neurodegeneration through a combination of literature reviews and examples of current research.
  table of contents: ""Front Cover""; ""Omic Studies of Neurodegenerative Disease: Part A""; ""Copyright""; ""Contents""; ""Contributors""; ""Preface""; ""Chapter One: AlzheimerÂ?s Disease: Genomics and Beyond""; ""1. Introduction""; ""2. GWASs on the Primary Phenotype of AD""; ""3. GWASs on the Secondary Phenotype of AD""; ""4. CNV Studies""; ""5. WES and WGS Studies""; ""6. Functional Genomics Studies""; ""7. Brain Transcriptome Studies""; ""8. Early-Onset AD""; ""9. Epigenomics Studies in the Brain""; ""10. AD, Brain Aging, and Longevity""; ""11. AD and Relevant Diseases""
  table of contents: 12. Seeking Peripheral Biomarkers13. Animal Studies of AD -- 14. iPSC Technology in AD Research -- 15. Integrating Multiomics Information for AD -- 16. Concluding Remarks -- Acknowledgments -- References -- Chapter Two: The Potential of Proteomics in Understanding Neurodegeneration -- 1. Introduction -- 2. Cellular Mechanisms of Neurodegeneration -- 3. Fundamentals of Proteomics -- 3.1. Common Proteomic Protocols -- 3.2. Specifics of Proteomic Protocols -- 4. Application of Proteomics in Neurodegenerative Diseases
  table of contents: ""4.1. Proteomic Approaches Using Animal Models""""4.2. Proteomic Approaches Using Human Cells and Tissue""; ""4.3. Proteomic Characterization of Biological Fluids for Biomarker Discovery""; ""4.3.1. ParkinsonÂ?s Disease""; ""4.3.2. AlzheimerÂ?s Disease""; ""4.3.3. HuntingtonÂ?s Disease""; ""4.3.4. Amyotrophic Lateral Sclerosis""; ""4.3.5. Other Neurodegenerative Diseases""; ""5. From Proteomics to Clinical Significance: Targeting Signaling Pathways in Neurodegenerative Diseases""; ""6. Future Perspectives: Combinatorial Genomic, Metabolomics, and Proteomic Analysis""; ""Acknowledgments""
  table of contents: ""7. HuntingtonÂ?s Disease""""7.1. Pathophysiology""; ""7.2. Mitochondrial Dysfunction in HD""; ""7.3. Oxidatively Modified Proteins in HD""; ""7.4. PTM Specific to htt Protein""; ""8. Prion Diseases""; ""8.1. Pathophysiology""; ""9. Prion Biomarkers""; ""9.1. Brain""; ""9.2. Cerebrospinal Fluid""; ""10. Amyotrophic Lateral Sclerosis""; ""10.1. Pathophysiology""; ""11. ALS Biomarkers""; ""11.1. Cerebrospinal Fluid""; ""11.2. Plasma""; ""11.3. Other Biofluids""; ""12. Conclusion""; ""References""; ""Chapter Four: Uncovering Neurodegenerative Protein Modifications via Proteomic Profiling""
  note: edited by Michael J. Hurley.
  note: Includes index.
  note: ""References""""Chapter Three: Proteomics Approach to Identify Biomarkers in Neurodegenerative Diseases""; ""1. Introduction""; ""2. Proteomic Methods Utilized in Understanding Neurodegenerative Diseases""; ""2.1. Two-Dimensional Gel Electrophoresis""; ""2.2. Mass Spectrometry""; ""3. AlzheimerÂ?s Disease""; ""3.1. Pathophysiology""; ""4. AD Biomarkers""; ""4.1. Brain Tissue""; ""4.2. Cerebrospinal Fluid""; ""4.3. Plasma""; ""5. ParkinsonÂ?s Disease""; ""5.1. Pathophysiology of ParkinsonÂ?s Disease""; ""6. PD Biomarkers""; ""6.1. Ccerebrospinal Fluid""; ""6.2. Plasma""; ""6.3. Brain Tissue""
  subject:
    topic: Nervous system
    topic: Degeneration
  subject:
    topic: Molecular neurobiology
  subject:
    topic: Neurobiologie moléculaire
  subject:
    topic: HEALTH & FITNESS
    topic: Diseases
    topic: General
  subject:
    topic: MEDICAL
    topic: Clinical Medicine
  subject:
    topic: MEDICAL
    topic: Diseases
  subject:
    topic: MEDICAL
    topic: Evidence-Based Medicine
  subject:
    topic: MEDICAL
    topic: Internal Medicine
  subject:
    topic: Molecular neurobiology
  subject:
    topic: Nervous system
    topic: Degeneration
  classification: RC365
  classification: 616.8/3
  related item:
    title info:
      title: Omic Studies of Neurodegenerative Disease - Part A
    name:
      name part: Hurley, Michael J.
    origin info:
      publisher: : Elsevier Science, ©2015
  related item:
    title info:
      title: International review of neurobiology ; v. 121
  identifier: 9780128016213
  identifier: 0128016213
  identifier: 9780128014806
  identifier: 0128014806
  identifier: 826191 MIL
  identifier: http://proxy.library.tamu.edu/login
  record info:
    record content source: N$T
    record creation date: 150831
    record change date: 20260326213734.4
    record identifier: in00005759550
    language of cataloging:
      language term: eng