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Stem cell and gene therapy for cardiovascular disease
Stem Cell and Gene Therapy for Cardiovascular Disease is a state-of-the-art reference that combines, in one place, the breadth and depth of information available on the topic. As stem cell and gene therapies are the most cutting-edge therapies currently available for patients with heart failure, each section of the book provides information on medical trials from contributors and specialists from around the world, including not only what has been completed, but also what is planned for future research and trials. Cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals will find this book an invaluable resource for further study on the topic.
""Front Cover""; ""Stem Cell and Gene Therapy for Cardiovascular Disease""; ""Copyright Page""; ""Contents""; ""List of Contributors""; ""Preface""; ""Regenerative Medicine and the Cardiovascular System: A Good Start""; ""Gene Therapy""; ""Tissue Engineering""; ""Dedication""; ""Acknowledgments""; ""References""; ""I. Stem Cells""; ""1 Introduction and Overview of Stem Cells""; ""What is Regenerative Medicine?""; ""What Defines a Stem Cell?""; ""Types of Stem Cells""; ""Stem Cell Sources""; ""Bone Marrow""; ""Adipose Tissue""; ""Heartâ€?Cardiac Resident Progenitor Cells""
""Somatic (Skin) Cells""""Umbilical Cord and Placenta""; ""Endometrial Tissue""; ""Dental Pulp""; ""Other Classifications of Stem Cells""; ""Autologous versus Allogeneic Cells""; ""Multipotent Adult Progenitor Cells""; ""Cardiopoiesis-Derived MSCs""; ""Mechanisms of Action of Stem Cells""; ""Endogenous versus Exogenous Tissue Repair""; ""Functional Assays""; ""Sex Differences""; ""Safety Profile""; ""Summary""; ""References""; ""2 Pathological Assessment of Experimental Models of Stem Cell and Other Regenerative Therapies""; ""Introduction""; ""Preparation and Labeling""
""BrdU Incorporation""""Fluorescence Labeling and Dye Marking""; ""Nuclear Dyes""; ""Cytoplasmic Dyes""; ""Genetic Markers""; ""Endogenous Markers""; ""Exogenous Markers""; ""Delivery Routes for Stem Cells and Other Biological Agents""; ""Delivery Through the Vasculature""; ""Intramyocardial Delivery""; ""Pathologic Assessment""; ""Gross Examination""; ""Tissue Sampling""; ""Triphenyltetrazolium Chloride Staining for Infarct Size Quantification""; ""Microscopic Assessment""; ""General Evaluation""; ""Histologic Findings""; ""Cell Characterization""
""Angiogenesis and Capillary Density Assessment""""Conclusion""; ""References""; ""3 Large Animal Models for Cardiac Cell Therapy""; ""Introduction""; ""Is There a Need for Large Animal Models of Cardiac Diseases?""; ""Considerations when Selecting an Animal Model""; ""Animal Care: the Ideal is Not Always Easy""; ""Physiological Parameters and Data Collection""; ""Cardiovascular Anatomy""; ""Cardiovascular Physiology""; ""Models of Myocardial Ischemia""; ""Acute Myocardial Ischemia""; ""Coronary Ligation versus Coronary Balloon Occlusion""; ""Microsphere Embolization""
""Inorganic Mercury Thrombosis""""Thrombus""; ""Cryothermia""; ""Chronic Myocardial Ischemia""; ""Ameroid Constrictor""; ""Models of Overload""; ""Volume Overload""; ""Pressure Overload""; ""Models of DCM""; ""Models of Cardiotoxicity""; ""Cell Therapy""; ""Bone Marrow Harvest in Porcine Models""; ""Delivery of Cell Therapy""; ""Open Surgical Transmyocardial Injection""; ""Transcatheter Percutaneous Approach""; ""Intracoronary and Retrograde Delivery""; ""Transmyocardial Injection: Mapping and Injection""; ""Conclusions""; ""References""; ""I. Bodyâ€?s Native Repair Mechanisms""
edited by Emerson C. Perin, M.D., Ph. D., FACC, Leslie W. Miller, M.D., Doris A. Taylor, Ph. D., FAHA, FACC, James T. Willerson, M.D., FAHA, FACC.
Includes bibliographical references and index.