http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
Mechanism of the anticancer effect of phytochemicals
1 online resource (xiii, 262 pages) : illustrations.
Volume 37 will provide details on the major chemical constituents of medicinal plants and their mechanism of action as the anticancer compounds. This special issue, in addition to the previous volume (volume 36 of the Enzyme series was on the topic of Natural Products and Cancer Signaling Targets: Isoprenoids, Polyphenols and Flavonoids), will highlight the significant advance made in the field in elucidating mechanisms of anticancer effect of the major phytochemicals. Key features: * Contributions from leading authorities * Informs and updates on all the latest developments in the field.
""Front Cover""; ""Mechanism of the Anticancer Effect of Phytochemicals""; ""Copyright""; ""Contents""; ""Contributors""; ""Preface""; ""Chapter One: How Phytochemicals Prevent Chemical Carcinogens and/or Suppress Tumor Growth?""; ""1. Introduction""; ""2. Phytochemicals Application in Chemoprevention Strategies""; ""2.1. Blocking Initiation/Reversing Promotion""; ""2.2. Activating Phase II Detoxifying Enzymes""; ""2.3. Prooxidant/Antioxidant Activities""; ""2.4. Protection Against Radiation""; ""2.5. Alteration in Signaling Pathways""; ""2.6. Effect on Cell-Cell Adhesion Machinery""
""2.7. Induction of Epigenetic Changes""""3. Phytochemicals Usage as Chemotherapeutic""; ""3.1. Inhibition of Enzymes""; ""3.1.1. Inhibition of Topoisomerases I or II""; ""3.1.2. Effect on Telomerase""; ""3.1.3. Other Enzymes""; ""3.2. Direct Binding to Biomacromolecules""; ""3.3. Epigenetic Alteration/Chromatin Modification""; ""3.3.1. Histone Modifications: Acetylation/Deacetylation and Methylation/Demethylation""; ""3.3.2. DNA Methylation Status""; ""3.4. RNA Modulation""; ""3.5. Autophagy and UPR68""; ""3.6. Apoptosis Induction""; ""3.7. Cell Cycle Arrest""
""3.8. Inhibiting Angiogenesis""""3.9. Adjuvant/Combinatorial Therapy""; ""4. Summary""; ""References""; ""Chapter Two: Quercetin and Tryptanthrin: Two Broad Spectrum Anticancer Agents for Future Chemotherapeutic Interventions""; ""1. Introduction""; ""2. Quercetin""; ""2.1. Source""; ""2.2. Biosynthesis""; ""2.3. Structure and Antioxidative Property""; ""2.4. Properties""; ""2.4.1. Antioxidant Property""; ""2.4.2. Free Radical Scavenging Activity""; ""2.4.3. Nitric Oxide Inhibitory Action""; ""2.4.4. Inhibition of Xanthine Oxidase""; ""2.4.5. Interaction with Other Enzyme Systems""
""2.5. Pharmacokinetics""""2.6. Role as an Anticancer Agent""; ""2.6.1. Cell Cycle Regulation""; ""2.6.2. QuercetinÂ?s Effect on Apoptosis""; ""2.6.3. Inhibition of Pathways Involved in Tumor Growth and Invasiveness""; ""2.7. QuercetinÂ?s Role as an Anti-Inflammatory Agent""; ""2.8. QuercetinÂ?s Influence on p53""; ""2.9. QuercetinÂ?s Nontoxicity Against Normal Cells""; ""2.10. QuercetinÂ?s Action Against Chemical-Induced Tumor and Xenograft""; ""2.11. Synergism with Other Drugs""; ""2.12. Clinical Study""; ""3. Tryptanthrin""; ""3.1. Chemistry""; ""3.2. Source""; ""3.3. Medicinal Value""
""3.4. Cytotoxic and Anticancer Properties of Tryptanthrin""""3.5. Structural Modification of Tryptanthrin for Increasing its Bioactivity""; ""3.6. Tryptanthrin Prevents Development of Cancer by the Inhibition of Various Molecular Events""; ""3.6.1. Antioxidant Activity""; ""3.6.2. Anti-Inflammatory Activity""; ""3.7. Angiogenesis""; ""3.8. Toxicological Analysis""; ""4. Conclusion""; ""Acknowledgement""; ""References""; ""Chapter Three: Potential Anticancer Properties and Mechanisms of Action of Withanolides""; ""1. Introduction""; ""2. Reactive Oxygen Species Signaling""
edited by S. Zahra Bathaie and Fuyuhiko Tamanoi.
Includes bibliographical references and indexes.
Enzymes. Volume 37, Mechanism of the anticancer effect of phytochemicals
Waltham, MA : Academic Press is an imprint of Elsevier, 2015