rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Drug design and discovery in Alzheimer's disease
  name:
    name part: Rahman, Atta-ur-
    name part: 1942-
    role:
      role term: editor.
  name:
    name part: Choudhary, Muhammad Iqbal
    role:
      role term: editor.
  name:
    name part: ScienceDirect (Online service)
  type of resource: text
  genre: bibliography
  genre: Electronic books.
  genre: Internet Resources.
  origin info:
    place:
      place term: ne
    date issued: 2014
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource
  abstract: Drug Design and Discovery in Alzheimer's Disease includes expert reviews of recent developments in Alzheimer's disease (AD) and neurodegenerative disease research. Originally published by Bentham as Frontiers in Drug Design and Discovery, Volume 6and now distributed by Elsevier, this compilation of the sixteen articles, written by leading global researchers, focuses on key developments in the understanding of the disease at molecular levels, identification and validation of molecular targets, as well as innovative approaches towards drug discovery, development, and delivery. Beginning with an.
  table of contents: Front Cover; Drug Design and Discovery in Alzheimer's Disease; Copyright; Contents; Preface; List of Contributors; Chapter 1: Pharmacotherapy of Alzheimer's Disease: Current State and Future Perspectives; Abstract; 1. Alzheimer's Disease -- Historic Overview; 2. Current Status and Prevalence of AD; 3. Risk Factors for AD; 4. Cholinergic Theory; 5. Cholinesterases; 6. Current Therapeutic Approaches to AD; 7. Conclusions; Acknowledgements; Conflict of Interest; References; Chapter 2: Challenges in Designing Therapeutic Agents for Treatingalzheimer's Disease-From Serendipity to Rationality.
  table of contents: AbstractIntroduction; Alzheimer's Disease (AD); Challenges in Designing Alzheimer's Medicines; Symptomatic Drugs; Disease Modifying Drugs (Investigative Approaches); Rational Approaches to Design AD Drugs; Multi-Target-Directed Ligand (MTDL) Design Strategy; Concluding Remarks & Future Prospects; Acknowledgements; Conflict of Interest; Abbreviations; References; Chapter 3: Enzyme Inhibitors Involved in the Treatment of Alzheimer's Disease; Abstract; Introduction; Pathophysiology of Alzheimer Disease; Overview on Key Enzymes Involved in Alzheimer's Disease.
  table of contents: Clinically Used Enzymes Inhibitors for Alzheimer's DiseaseCurrent Enzyme-Targeted Drug Development Foralzheimer's Disease; Conclusions; Acknowledgements; Conflict of Interest; Abbreviations; References; Chapter 4: Towards Small Molecules as Therapies for Alzheimer's Disease and Other Neurodegenerative Disorders; Abstract; Introduction to Neurodegenerative Diseases; Alzheimer's Disease: Etiology and the ß-Amyloid Hypothesis; BACE1 and the ß-Amyloid Hypothesis; The Evolution of BACE1 Inhibitors; BACE1 Inhibitors: Uncovering "Chemical Truffles" in Pre-Clinical Drug Discovery.
  table of contents: HD and Mitochondrial DysfunctionThe Synergy Between Aggregation and Autophagy; Transcriptional Regulation; Other Biological Pathway Deficits; Perspectives for HD; Conclusive Remarks; Acknowledgements; Conflict of Interest; Abbreviations; References; Chapter 5: Multifunctional Enzyme Inhibition for Neuroprotection -- A Focus on MAO, NOS, and AChE Inhibitors; Abstract; Introduction; Monoamine Oxidase -- Isoforms and Function; Nitric Oxide Synthase (NOS) -- Isoforms and Structure; Acetylcholinesterase -- Structure and Function; Conclusion and Future Developments; Acknowledgements.
  note: edited by Att-ur-Rahman, FRS, Honorary Life Fellow, Kings College, University of Cambridge, UK and Muhammad Iqbal Choudhary, H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Pakistan.
  note: Includes bibliographical references and index.
  subject:
    topic: Alzheimer's disease
    topic: Chemotherapy
  subject:
    topic: Alzheimer's disease
    topic: Treatment
  subject:
    topic: Drugs
    topic: Design
  subject:
    topic: Alzheimer Disease
    topic: drug therapy
  subject:
    topic: Drug Delivery Systems
  subject:
    topic: Drug Design
  subject:
    topic: Maladie d'Alzheimer
    topic: Chimiothérapie
  subject:
    topic: Maladie d'Alzheimer
    topic: Traitement
  subject:
    topic: Médicaments
    topic: Conception
  subject:
    topic: HEALTH & FITNESS
    topic: Diseases
    topic: General
  subject:
    topic: MEDICAL
    topic: Clinical Medicine
  subject:
    topic: MEDICAL
    topic: Diseases
  subject:
    topic: MEDICAL
    topic: Evidence-Based Medicine
  subject:
    topic: MEDICAL
    topic: Internal Medicine
  subject:
    topic: MEDICAL
    topic: Chemotherapy
  subject:
    topic: Alzheimer's disease
    topic: Chemotherapy
  subject:
    topic: Alzheimer's disease
    topic: Treatment
  subject:
    topic: Drugs
    topic: Design
  classification: RC523
  classification: 616.8/31061
  classification: WT 155
  related item:
    title info:
      title: Drug Design and Discovery in Alzheimer's Disease
    name:
      name part: Atta-ur-Rahman.
    origin info:
      publisher: Burlington : Elsevier Science, ©2015
  identifier: 9780128039601
  identifier: 0128039604
  identifier: 9780128039595
  identifier: 0128039590
  identifier: http://proxy.library.tamu.edu/login
  record info:
    record content source: N$T
    record creation date: 150630
    record change date: 20260407211219.8
    record identifier: in00005759251
    language of cataloging:
      language term: eng