http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
Epigenetic Cancer Therapy unites issues central to a translational audience actively seeking to understand the topic. It is ideal for cancer specialists, including oncologists and clinicians, but also provides valuable information for researchers, academics, students, governments, and decision-makers in the healthcare sector. The text covers the basic background of the epigenome, aberrant epigenetics, and its potential as a target for cancer therapy, and includes individual chapters on the state of epigenome knowledge in specific cancers (including lung, breast, prostate, liver). The bo.
Front Cover; Epigenetic Cancer Therapy; Copyright Page; Contents; List of Contributors; 1 Introduction; 1 Introduction to the Area (Key Concepts); 2 Epigenetics and Cancer; 3 Targeting Aberrant Epigenetics; 4 Issues to Overcome/Areas of Concern; 5 Future Directions: Translation to the Clinic; References; 1 Introduction and Key Concepts; 2 DNA Methylation and Hydroxymethylation in Cancer; 1 Introduction; 2 Epigenetics; 2.1 Chromatin Structure; 2.2 DNA Methylation in Cellular Homeostasis; 2.2.1 Genomic distribution of DNA methylation; 2.2.2 Functional role of DNA methylation.
2.2.3 DNA methyltransferases2.2.4 Recruitment of DNMTs; 2.3 DNA Demethylation; 3 DNA Methylation Patterns in Cancer; 3.1 Hypermethylation in Cancer; 3.2 Hypomethylation in Cancer; 3.3 Methods for 5mC Detection; 4 Aberrations of Enzymes Involved in DNA Methylation Homeostasis in Cancer; 4.1 DNA Methyltransferase; 4.2 TET Proteins; 4.3 Isocitrate Dehydrogenases; 4.4 Succinate Dehydrogenases; 5 DNA Hydroxymethylation in Cancer; 5.1 Methods for 5hmC Detection; 5.1.1 Affinity-based enrichment approach; 5.1.2 Chemical methods; 5.1.3 Quantitative methods at single base resolution.
5.1.4 Third-generation sequencing5.2 DNA Hydroxymethylation Patterns in Cancer; 6 Conclusion; References; 3 Writers, Readers, and Erasers of Epigenetic Marks; 1 Introduction; 2 Writers; 2.1 DNA Methyltransferases; 2.2 Histone Lysine Methyltransferases; 2.3 Protein Arginine Methyltransferases; 2.4 Histone Acetyltransferases; 3 Readers; 3.1 Methyl-CpG-Binding Proteins; 3.2 Histone Methylation-Binding Domains; 3.3 Histone Acetylation-Binding Domains; 4 Erasers; 4.1 Proteins Involved in DNA Demethylation; 4.2 Histone Demethylases; 4.3 Histone Deacetylases (HDACs).
5 Interactions between the Various Components6 Epigenetics and Cancer; 6.1 DNA Methylation and Cancer; 6.2 Histone Methylation and Cancer; 6.3 Histone Acetylation and Cancer; 7 Epigenetic Proteins as Therapeutic Targets; 8 Conclusion and Future Opportunities; References; 4 MicroRNAs and Cancer; 1 miRNA Biogenesis and Functionality; 2 miRNAs in Cancer Biology; 3 miRNA: An Epigenetic Perspective; 3.1 Epigenetic Alteration of miRNA Expression; 3.2 Epi-miRNA; 3.3 miRNA with Epigenetic Functions; 4 miRNA Epigenetic Therapy; 4.1 miRNA Inhibition in Cancer; 4.2 miRNA Replacement in Cancer.
4.3 Small-Molecule-Based miRNA Modulation5 Future Perspectives; Acknowledgments; References; 5 Long Noncoding RNAs and Cancer; 1 Introduction; 2 Classification and Nomenclature of lncRNAs; 2.1 Classification; 2.2 Nomenclature; 3 Mechanisms of lncRNA Function; 3.1 lncRNAs as Decoys and Guides; 3.2 lncRNAs as Scaffolds; 3.3 lncRNAs as Signaling Molecules; 3.4 miRNA Sequestration; 3.5 lncRNAs and Epigenetic Regulation; 3.5.1 H19; 3.5.2 AIR and KCNQ1OT1; 3.5.3 lincRNAs; 4 lncRNAs and Human Disease; 4.1 Prognostic Markers; 4.1.1 lncRNAs in the circulation.
Academic Press is an imprint of Elsevier.
Includes bibliographical references at the end of each chapters and index.