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Biomaterials and medical device-associated infections
1 online resource (281 pages) : illustrations, tables.
Despite advances in materials and sterilisation, patients who receive biomaterials of medical device implants are still at risk of developing an infection around the implantation site. This book reviews the fundamentals of biomaterials and medical device related infections and methods and materials for the treatment and prevention of infection. The first part of the book provides readers with an introduction to the topic including analyses of biofilms, diagnosis and treatment of infection, pathology and topography. The second part of the book discusses a range of established and novel technologies and materials which have been designed to prevent infection.
Cover; Biomaterials and Medical Device-associated Infections; Copyright; Contents; List of contributors; Woodhead Publishing Series in Biomaterials; Part One Introduction to biomaterials and medical device-related infections; 1 Introduction to biomaterials and medical device-associated infections; 1.1 History of biomaterials; 1.2 Overview of current medical devices and applications; 1.3 Overview of problems associated with medical devices; 1.4 Introduction to the structure of this book; References; 2 Biofilms and implant-associated infections; 2.1 Introduction
2.2 Microbial profile of implant-associated infections2.3 Relevance of biofilms in implant-associated infections; 2.4 Structure and composition of biofilms; 2.5 Pathogenesis of biofilm infection; 2.6 Future trends; 2.7 Further information and advice; References; 3 In vivo infection studies; 3.1 Introduction; 3.2 Legitimacy of animal studies; 3.3 Choosing the right animal model to study device-associated infections; 3.4 Pros and cons of in vivo infection studies; 3.5 Correlation of outcome between animal and clinical studies; 3.6 Conclusion and future trends
3.7 Sources of further information and adviceAcknowledgments; References; 4 Diagnosis of biofilm-associated infections in medical devices; 4.1 Introduction; 4.2 Importance of detection of biofilm; 4.3 Sites of biofilm formation; 4.4 Collection of samples for biofilm detection; 4.5 Examples of methods for the detection of biofilms associated with infections; 4.6 Future trends; 4.7 Conclusion; Acknowledgement; References; 5 Diagnosis and treatment of implant-associated infections; 5.1 Introduction; 5.2 Risk factors and prevention; 5.3 Diagnosis; 5.4 Treatment; 5.5 Future trends; References
Part Two Technologies and materials for controlling biofilms6 Surface modification of biomaterials for biofilm control; 6.1 Introduction; 6.2 Principles of bacterial cell-biomaterial surface interactions; 6.3 Substrate specific biological response; 6.4 Looking at nature for inspiration; 6.5 Modifications to prevent initial stages of bacterial adhesion; 6.6 Methods to prevent irreversible attachment of microorganisms; 6.7 Mitigation of biofilm formation by attached organisms; 6.8 Future trends; References; 7 Surface nanoengineering for combating biomaterials infections; 7.1 Introduction
7.2 Modification of surface nano topography to inhibit bacterial adhesion7.3 Surface functionalization with eluting antibacterial agent; 7.4 Surface functionalization with anti-adhesive polymers; 7.5 Immobilization of bactericidal moieties on surfaces; 7.6 Conclusion and future trends; 7.7 Sources of further information and advice; References; 8 Bioactive biomaterials for controlling biofilms; 8.1 Introduction; 8.2 Definition of medical device; 8.3 Biomaterials; 8.4 Biomaterial applications in medical devices; 8.5 Post-implantation device-associated infections
edited by L. Barnes and I.R. Cooper ; contributors, Y. Achermann [and thirty-one others].
Includes bibliographical references at the end of each chapters and index.
Woodhead Publishing series in biomaterials ; no. 86