rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Molecular targets in protein misfolding and neurodegenerative disease
  name:
    name part: Seneci, Pierfausto
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: ScienceDirect (Online service)
  type of resource: text
  genre: bibliography
  genre: Electronic books.
  origin info:
    place:
      place term: enk
    date issued: 2015
    copyright date: 2015
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource (314 pages) : illustrations (some color)
  abstract: Aimed at "drug discoverers"--I.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular - the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation, druggability, existing leads, etc.). Together these will satisfy the needs of various audiences, including in vitro biologists, pharmacologists, medicinal chemists, etc
  table of contents: Cover; Title Page; Copyright Page; Dedication; Contents; Abbreviations; Chapter 1 -- Protein Misfolding, Neurodegeneration and Tau; 1.1 -- The neurodegeneration scenario; 1.2 -- Protein folding: physiological benefits and pathological consequences; 1.3 -- Tau: An intrinsically disordered, flexible, and aggregation-prone protein; 1.4 -- Tauopathies: Aggregation-prone tau in neurodegenerative disease (NDD); 1.4.1 -- Class 0 Tauopathies; 1.4.2 -- Class I Tauopathies; 1.4.3 -- Class II Tauopathies; 1.4.4 -- Class III Tauopathies; 1.4.5 -- Class IV Tauopathies; 1.4.6 -- Tau Mutations; References.
  table of contents: Chapter 2 -- Targeting the Protein Quality Control (PQC) Machinery2.1 -- Molecular chaperones, PQC, and neurodegeneration; 2.2 -- Molecular targets; 2.2.1 -- Hsp27; 2.2.2 -- Hsp70; 2.2.3 -- Hsp90; 2.3 -- Disease-modifying compounds; References; Chapter 3 -- Proteasomal Degradation of Soluble, Misfolded Proteins; 3.1 -- UPS-mediated degradation of misfolded proteins; 3.2 -- UPS-mediated degradation of misfolded proteins in NDDs; 3.3 -- UPS-targets; 3.3.1 -- CHIP; 3.3.2 -- USP14; 3.4 -- Disease-modifying compounds; References; Chapter 4 -- Unselective Disposal of Cellular Aggregates.
  table of contents: 4.1 -- Autophagy-mediated degradation of protein aggregates4.2 -- Autophagy-mediated degradation of protein aggregates in NDDs; 4.3 -- Macroautophagy-targets; 4.3.1 -- mTORC1; 4.4 -- Disease-modifying compounds; References; Chapter 5 -- Selective Disposal of Insoluble Protein Aggregates; 5.1 -- Aggrephagy-mediated degradation of protein aggregates; 5.2 -- Selective autophagy-mediated degradation of protein aggregates in NDDs; 5.3 -- Selective autophagy-targets; 5.3.1 -- p62; 5.3.2 -- HDAC6; 5.4 -- Disease-modifying compounds; References; Chapter 6 -- Assembly and Disassembly of Protein Aggregates.
  table of contents: 6.1 -- Introduction6.2 -- Disordered protein aggregates and ordered amyloid fibrils; 6.2.1 -- The Target: Interfering with (Neuro)toxic Tau Species in the Aggregation Process; 6.3 -- Chaperone-driven disaggregation of protein aggregates; 6.3.1 -- The Target: Hsp110; 6.4 -- Disease-modifying compounds; References; Conclusions; Index.
  note: Pierfausto Seneci.
  note: Includes bibliographical references at the end of each chapters and index.
  subject:
    topic: Molecular neurobiology
  subject:
    topic: Nervous system
    topic: Diseases
  subject:
    topic: Tauopathies
    topic: drug therapy
  subject:
    topic: Tauopathies
    topic: etiology
  subject:
    topic: Nervous System Diseases
  subject:
    topic: Molecular Targeted Therapy
    topic: methods
  subject:
    topic: Protein Folding
    topic: drug effects
  subject:
    topic: Neurobiologie moléculaire
  subject:
    topic: Système nerveux
    topic: Maladies
  subject:
    topic: SCIENCE
    topic: Life Sciences
    topic: Zoology
    topic: General
  subject:
    topic: Molecular neurobiology
  subject:
    topic: Nervous system
    topic: Diseases
  classification: QP356.2 .S464 2015eb
  classification: 591.188
  related item:
    title info:
      title: Molecular targets in protein misfolding and neurodegenerative disease
    name:
      name part: Seneci, Pierfausto.
    origin info:
      publisher: London : Academic Press, ©2015
    physical description:
      extent: xvii, 295 pages
  identifier: 9780128004999
  identifier: 0128004991
  identifier: 0128001860
  identifier: 9780128001868
  identifier: 1322639523
  identifier: 9781322639529
  identifier: 695234 MIL
  identifier: http://proxy.library.tamu.edu/login
  record info:
    record content source: E7B
    record creation date: 141016
    record change date: 20260326211326.1
    record identifier: in00005757100
    language of cataloging:
      language term: eng