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International Symposium on Early Diabetes 1968 : Marbella, Spain)
1 online resource (xxi, 486 pages) : illustrations
Advances in Metabolic Disorders, Supplement 1: Early Diabetes covers the discussions during the first International Symposium on Early Diabetes. The book discusses the views of the role of genetic factors in diabetes; the genetic problem posed by the relatively high frequency of diabetes; the relationship between diabetes and prediabetes in the mother; and the congenital defect in the offspring. The text also describes the report on the genetics of diabetes among the Pima Indians, as well as the genetics of animals with spontaneous diabetes. The pathophysiology of diabetes mellitus, the conce.
Front Cover; Early Diabetes; Copyright Page ; List of Contributors ; Foreword; Preface; Table of Contents; PART I: GENETICS OF DIABETES; Chapter 1. The Genetics of Diabetes Mellitus; Views of the Role of Genetic Factors in Diabetes; The Genetic Problem Posed by the Relatively High Frequency of Diabetes; Diabetes and Congenital Defect; REFERENCES; Chapter 2. Preliminary Report on the Genetics of Diabetes among the Pima Indians; Summary; ACKNOWLEDGMENTS; REFERENCES; Chapter 3. Genetics of Animals with Spontaneous Diabetes; REFERENCES; DISCUSSION; PART II: PATHOPHYSIOLOGY.
Chapter 4. Some Factors Controlling Differentiation and/or Modulation of Rat Pancreatic Islet CellsSummary and Conclusions; REFERENCES; Chapter 5. A Two-Compartmental Model for Insulin Secretion; Model for Insulin Secretion; Material and Methods; Results and Discussion; Summary and Conclusions; REFERENCES; Chapter 6. Mechanisms in the Control of Insulin Release by Glucose and Other Substances; Glucose as an Effector of Insulin Release; Glucose Metabolism by Mouse Pancreatic Islets; Glucose Phosphorylating Enzymes in Mouse Pancreatic Islets.
GIucose-6-Phosphatase Activity of Mouse Pancreatic IsletsPossible Glucoreceptor Mechanisms; REFERENCES; Chapter 7. The Mechanism of Insulin Secretion Studied through the Effects of Electrolytes and Inhibitors; Effects of Electrolytes on Insulin Secretion; The Mechanism of Insulin Secretion; Inhibitors of Insulin Secretion; Conclusions; REFERENCES; DISCUSSION; Chapter 8. Insulin Seeretion in Early Diabetie Animals: In Vivo Studies; Methods; Results; Discussion and Conclusion; REFERENCES; Chapter 9. Diabetogenesis; Spontaneously Diabetic Animals; Induced Insulin Deficiency; Diabetogenic Factors.
Human Diabetes: Facts and HypothesesREFERENCES; Chapter 10. The Effect of ß-Adrenergic Receptor Blocking Agents on Drug-Induced Insulin Secretion; Introduction; Materials and Methods; Results; Discussion; REFERENCES; Chapter 11. Dynamics of Insulin Secretion in Early Diabetes in Humans; Results; Discussion; REFERENCES; Chapter 12. Evidence that the Primary Lesion in Familial Diabetes Mellitus Is an Inherited Defect of the ß-Cell; Methods and Results; Discussion; Summary; REFERENCES; Chapter 13. Subnormal Secretion of Insulin in Mild Diabetes Mellitus; REFERENCES; DISCUSSION.
Chapter 14. Possible Role oî Insulin-Stimulating Hormones in Disturbances of Nutrient ToleranceIntroduction; Enterohumoral Deficiency as a Cause of Impaired Insulin Response; Extragastrointestinal Betacytotrophic Hormone Deficiency as a Cause of Impaired Insulin Response; Pancreatic Glucagon Response in Overt Diabetics; REFERENCES; DISCUSSION; Chapter 15. Evidence for an Abnormal Insulin in Diabetes Mellitus; REFERENCES; Chapter 16. Metabolism of Insulin in Normal and Diabetic Subjects; Summary; REFERENCES.
edited by Rafael A. Camerini-Dávalos, Diabetes Center and Department of Medicine, New York Medical College, New York, New York and Harold S. Cole, Diabetes Center and Department of Pediatrics, New York Medical College, New York, New York ; associate editor, William S. Gailmor, New York, New York.
Includes bibliographical references and index.
International Symposium on Early Diabetes (1st : 1968 : Marbella, Spain).