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basic concepts for interdisciplinary applications
"Introductory Immunology quickly acquaints readers with natural immune responses manifesting in diseases and disorders. The book presents a complete picture of natural defenses to infectious agents, as well as the mechanisms that lead to autoimmune dysfunction. In addition, it examines immunologically based diseases, giving the reader sufficient knowledge to make sound clinical decisions leading to better treatment outcomes. Introductory Immunology is aimed at researchers, postgraduates, or any scientifically inclined reader interested in immunology. No prior expertise in medical, biochemical, or cellular science is needed to benefit from the clear presentation of immunology concepts in this book. Quick, concise introduction to immunological concepts. Breaks down all of immunology into manageable, logically digestible building blocks. Geared toward readers without medical, biochemical, or cellular expertise."
Front Cover; Introductory Immunology; Copyright Page; Contents; Preface; Dedication; Preface; Acknowledgments; 1 A Functional Overview of the Immune System and Immune Components; Immune Homeostasis; Self vs. Non-Self; Innate and Adaptive Immunity; Anatomy of the Immune System; Cells of the Immune System; First Line Defenders: The Myeloid Cells; Adaptive Avengers: The Lymphoid Cells; Lymphocytes; Cluster of Differentiation; Summary; 2 The Inflammatory Response; Inflammation; Initiation of the Inflammatory Response; Role of Antibodies in Inflammation; Biological Functions of Complement.
Activation and Directed Migration of LeukocytesPathogen Recognition and Cytokine Signaling; Feedback and Adaptation from a Distance; Summary; 3 The B Lymphocyte and the Humoral Response; B Lymphocytes Produce Antibodies; Structural Characteristics of Immunoglobulins; Immunoglobulin Nomenclature; Biologic Properties of Antibody Isotypes; IgD; IgM; IgG; IgA; IgE; Kinetics of Antibody Response; Membrane-Bound Immunoglobulin; Development of B Cells; Gene Recombination; Development and Selection of Mature B Cells; Activation and Differentiation of B Cells; Summary.
Immune Homeostasis and Pathogenic OrganismsMajor Immune Defense Mechanisms Against Pathogens; Physical Barriers to Infection; Anatomic Barrier; Physiologic Barrier; Phagocytic and Endocytic Barriers; Inflammatory Barriers; Bacterial Infections; Microbial Motifs Detected Through Pattern-Recognition Receptors; Mycobacterial Infections; Viral Infections; Human Immunodeficiency Virus; Parasitic Infections (Helminths); Fungal Infections; Evasion of Immune Response; Summary; 6 Basic Disorders of Immune Function; Immunodeficiency Disorders; Genetic Basis for Primary Immunodeficiency.
Innate DeficienciesChronic Granulomatous Disease; Leukocyte Adhesion Deficiency; Chediak-Higashi Syndrome; Complement Disorders; Innate Pattern-Recognition Receptor Disorders; Adaptive Immune Disorders; X-Linked (Bruton's) Agammaglobulinemia (X-LA); Selective IgA Deficiency; Common Variable Immunodeficiency; Hyper IgM Disorders; DiGeorge Syndrome; Wiskott-Aldrich Syndrome; Severe Combined Immunodeficiency; Treatment of Immunodeficiency Diseases; Immunodeficiency as a Predisposition to Disease; Human Immunodeficiency Virus and Acquired Immunodeficiency Syndrome; Summary.