rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Telomeres in health and disease
  name:
    name part: Calado, Rodrigo.
  name:
    name part: ScienceDirect (Online service)
  type of resource: text
  genre: Electronic books.
  origin info:
    place:
      place term: vtu
    place:
      place term: Burlington
    publisher: Elsevier Science
    date issued: 2014
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource (205 pages)
  abstract: This special volume of Progress in Molecular Biology and Translational Science focuses on telomeres in health and disease. This volume covers a variety of topics with reviews written by experts in the field. Contributions from specialists in telomere diseases Informs and updates on how telomere dysfunction may cause disease in humans.
  table of contents: Front Cover; Telomeres in Health and Disease; Copyright; Contents; Contributors; Preface; Chapter One: Telomere and Telomerase Biology; 1. Introduction; 2. The General Structure of Telomeric DNA; 2.1. Telomere loops and G-quartets: Specialized structures at the ends of eukaryotic chromosomes; 3. Replication of Telomeres; 3.1. The telomerase RNP complex; 3.1.1. The reverse transcriptase component; 3.1.2. Telomerase accessory factors; 3.1.3. The telomerase RNA component; 3.1.4. How telomeres are replicated by telomerase; 3.1.5. Regulation of telomerase activity in mammals.
  table of contents: 3.2. Telomere replication in the absence of telomerase4. Telomeric Chromatin: Implications for End Protection, Telomere Replication, and Telomere Length Regulation; 4.1. CST: The major telomere end-binding complex on eukaryotic telomeres; 4.2. Shelterin: A conserved, double-stranded, telomeric protein complex that associates with the telomere end-binding CST ... ; 5. TERRA: The Telomeric RNA Transcript; 6. Consequences of Telomere Deprotection; Acknowledgments; References; Chapter Two: Human Telomeres and Telomere Biology Disorders; 1. Introduction; 2. Telomere Biology in Humans.
  table of contents: 2.1. Telomeric structure2.2. Telomerase and telomere-associated proteins; 2.3. Alternative lengthening of telomeres; 2.4. Measuring TL; 3. What Is a TBD?; 4. Clinical Features of the TBDs; 4.1. Dyskeratosis congenita; 4.2. Hoyeraal-Hreidarsson syndrome; 4.3. Revesz syndrome; 4.4. Coats plus syndrome/CRMCC; 4.5. Aplastic anemia; 4.6. Pulmonary fibrosis; 4.7. Nonalcoholic/noninfectious liver disease; 4.8. Genetic anticipation; 5. Germ-Line Genetics of TBDs; 6. Diagnosing TBDs; 7. Genetic Counseling Considerations; 8. Clinical Management; 8.1. Bone marrow failure; 8.2. Pulmonary fibrosis.
  table of contents: 9. Summary and Future DirectionsAcknowledgments; References; Chapter Three: Telomere Biology in Stem Cells and Reprogramming; 1. Introduction; 1.1. A variety of stem cells throughout organismal development; 1.2. Telomeres cap chromosomal ends; 2. Telomere Homeostasis in Stem Cells; 2.1. Telomerase activity in pluripotent stem cells; 2.2. Telomerase activity in adult multipotent cells; 2.2.1. Hematopoietic system; 2.2.2. Hair follicle stem cells; 2.2.3. Intestinal stem cells; 2.2.4. Muscle stem cells; 2.2.5. Neural stem cells; 2.2.6. Spermatogonial stem cells.
  table of contents: 2.3. Organismal consequences of telomere attrition in stem cells2.4. Noncanonical roles of telomerase in stem cell regulation; 3. Cellular Reprogramming; 3.1. Somatic cell nuclear transfer and cell fusion; 3.1.1. Telomere biology in SCNT; 3.2. Reprogramming through induced pluripotency; 3.2.1. Telomere reprogramming in iPS cells; 3.2.2. Derivation of IPS cells harboring disease-associated telomerase mutations; 4. Conclusions; References; Chapter Four: Telomere Dynamics and Aging.
  note: edited by Rodrigo T. Calado.
  note: 1. Introduction: Telomere Structure, Determinants of Telomere Dynamics, Measurement Parameters, and Regulation Mechanisms.
  subject:
    topic: Telomerase
  subject:
    topic: Télomérase
  subject:
    topic: SCIENCE
    topic: Life Sciences
    topic: Biochemistry
  subject:
    topic: Telomerase
  classification: QH600.3
  classification: QP606.T44
  classification: QU470
  classification: 572.8/7 572.87
  related item:
    title info:
      title: Telomeres in Health and Disease
    name:
      name part: Calado, Rodrigo.
    origin info:
      publisher: Burlington : Elsevier Science, ©2014
  related item:
    title info:
      title: Progress in molecular biology and translation science ; v. 125
  identifier: 9780123979094
  identifier: 0123979099
  identifier: 9780123978981
  identifier: http://proxy.library.tamu.edu/login
  record info:
    record content source: EBLCP
    record creation date: 140705
    record change date: 20260326205729.5
    record identifier: in00005755601
    language of cataloging:
      language term: eng