rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Advances in protein chemistry and structural biology
    sub title: STRUCTURAL GENOMICS
  name:
    name part: ScienceDirect (Online service)
  type of resource: text
  genre: Electronic books.
  origin info:
    place:
      place term: cau
    place:
      place term: SAN DIEGO
    publisher: ELSEVIER ACADEMIC Press
    date issued: 2009
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource (volumes)
  abstract: Structural genomics is the systematic determination of 3-dimensional structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome. While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large scale cloning, expression and purification. One main advantage of this approach is economy of scale. Key Features *Examines the three dimensional structure of all proteins of a given organism, by experimental methods such as X-ray crystallography and NMR spectroscopy * Looks at structural genomics as a foundation of drug discovery as discovering new medicines is becoming more challenging and the pharmaceutical industry is looking to new technologies to help in this mission.
  table of contents: Cover; ADVANCES IN PROTEIN CHEMISTRY AND STRUCTURAL BIOLOGY; Copyright Page; Contents; Chapter 1 Preparation and Characterization of Bacterial Protein Complexesfor Structural Analysis; Abstract; I. Introduction; II. Protein Complexes of Bacteria; III. Preparation of Bacterial Protein Complexes; IV. Characterization of Protein Complexes.; V. Experimental Determination of the Structure of Protein Complexes; VI. Examples of Characterization of Bacterial Protein Complexes; VII. Future Perspectives; Acknowledgment; References.
  table of contents: Chapter 2 Strategies for the Cloning and Expression of Membrane ProteinsAbstract; I. Introduction; II. From Past to Present: Practical Observations Regarding Membrane Protein Expression; III. Considerations for the HTP Expression of Membrane Proteins; IV. Structural Studies of GPCRs; V. Considerations for the Expression of Ion Channels; VI. Conclusions; References; AUTHOR INDEX; SUBJECT INDEX; Color Plates.
  subject:
    topic: Genomics
  subject:
    topic: Genomics
  subject:
    topic: Génomique
  subject:
    topic: Genomics
  classification: QD
  classification: 572.8/6
  related item:
    title info:
      title: Advances in protein chemistry and structural biology
    name:
      name part: Joachimiak, Andrzej.
    origin info:
      publisher: Burlington : Elsevier Science & Technology, ©2009
  related item:
    title info:
      title: Advances in protein chemistry and structural biology ; v. 76
  identifier: 0080922384
  identifier: 9780080922386
  identifier: 9780123744425
  identifier: 0123744423
  identifier: 261824 MIL
  identifier: http://proxy.library.tamu.edu/login
  record info:
    record content source: CNSPO
    record creation date: 131216
    record change date: 20260326200325.3
    record identifier: in00005753934
    language of cataloging:
      language term: eng