rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Inhibitors of the Ras superfamily g-proteins
    part number: Part A
  name:
    name part: Tamanoi, Fuyuhiko.
  name:
    name part: ScienceDirect (Online service)
  type of resource: text
  genre: bibliography
  genre: Electronic books.
  origin info:
    place:
      place term: mau
    date issued: 2013
    edition: First edition.
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource (361 pages) : illustrations (some color)
  abstract: This special volume of The Enzymes is targeted toward researchers in biochemistry, molecular and cell biology, pharmacology, and cancer. This thematic volume discusses inhibitors of the Ras superfamily G-proteins. Key features: * Contributions from leading authorities * Informs and updates on all the latest developments in the field.
  table of contents: Front Cover; Inhibitors of the Ras Superfamily G-proteins, Part A; Copyright; Contents; Preface; Chapter One: The Ras Superfamily G-Proteins; 1. The Ras Superfamily G-Proteins; 2. Overview of Structure, Activity, and Regulatory Proteins; 2.1. Three-dimensional structure; 2.2. GEF and GAP regulate the activities of the Ras superfamily G-proteins; 2.3. Posttranslational modification and membrane association; 3. Upstream and Downstream Signaling Pathways; 4. Significance in Human Cancer; 5. Strategies to Inhibit the Ras Superfamily G-Proteins; Acknowledgments; References
  table of contents: Chapter Two: NMR Study to Identify a Ligand-Binding Pocket in Ras1. KRAS as a Drug Target; 2. Nuclear Magnetic Resonance Fragment Screen; 2.1. Introduction; 2.2. The design of NMR fragment-screening cascade against KRas4B G12D mutant; 2.3. The fragment library; 2.4. The ligand-based primary screen; 2.5. Hit validation using protein-observed NMR; 2.6. FH2L using Kd determinations based on protein-observed NMR; 3. Protein Ligand Co-structures; 3.1. The crystal structure of KRas4BG12D (KRasm); 3.2. The high-resolution view of ligand and KRasm interaction
  table of contents: 3.3. The ligand-binding pocket expands upon DCAI binding4. Inhibition of SOS1-Mediated Nucleotide Exchange for RAS; 5. Ligand-Binding Sites on Ras; 6. Summary and Conclusions; References; Chapter Three: The Allosteric Switch and Conformational States in Ras GTPase Affected by Small Molecules; 1. Introduction; 2. Ras Architecture: The G Domain and Its Function; 3. The Allosteric Switch in Ras-GTP and Its Role in Intrinsic Hydrolysis; 4. The Allosteric Switch Linked to the Ras/Raf/MEK/ERK Pathway; 5. Most Ras Structures in the Protein Data Bank are in the R State
  table of contents: 6. Modulation of the Allosteric States in Ras-GTP by Small Molecules7. Mapping the Binding Site Hot Spots in Ras: Targeting the Protein/Membrane Interface; 8. Conclusions; References; Chapter Four: State 1(T) Inhibitors of Activated Ras; 1. Introduction; 2. Allosteric Regulation of the Ras-Effector Interaction; 3. Identification of State 1(T) in Activated Ras by NMR Spectroscopy; 4. Identification of 1(T) Inhibitors by NMR Spectroscopy; 5. Metal-Cyclen Derivatives as 1(T) Inhibitors; 6. Metal-BPA Derivatives as 1(T) Inhibitors; 7. Outlook: Possible Applications to Other Small GTPases
  note: edited by Fuyuhiko Tamanoi.
  note: Includes bibliographical references and indexes.
  note: English.
  subject:
    topic: Ras proteins
  subject:
    topic: G proteins
  subject:
    topic: ras Proteins
  subject:
    topic: GTP-Binding Proteins
  subject:
    topic: Protéines ras
  subject:
    topic: Protéines G
  subject:
    topic: SCIENCE
    topic: Life Sciences
    topic: Biochemistry
  subject:
    topic: G proteins
  subject:
    topic: Ras proteins
  classification: QP552.G16 E59 2013eb
  classification: 572/.696
  related item:
    title info:
      title: Inhibitors of the Ras superfamily g-proteins. Part A
    origin info:
      edition: First edition.
  related item:
    title info:
      title: Enzymes ; v. 33
  identifier: 9780124169678
  identifier: 0124169678
  identifier: 9780124167490
  identifier: 0124167497
  identifier: http://proxy.library.tamu.edu/login
  record info:
    record content source: E7B
    record creation date: 130919
    record change date: 20260326195329.8
    record identifier: in00005752974
    language of cataloging:
      language term: eng