Clinical biochemistry : metabolic and clinical aspects /
Essential reading for candidates for the MRCPath examination and similar postgraduate examinations in clinical biochemistry. The book gives an overview of the acquisition of data, as well as concentrating on clinical aspects of the subject, giving detailed coverage of all conditions where clinical b...
| Uniform Title: | Clinical biochemistry (Churchill Livingstone) |
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| Corporate Author: | |
| Other Authors: | , , , |
| Format: | eBook |
| Language: | English |
| Published: |
Edinburgh ; New York :
Churchill Livingstone/Elsevier,
2014.
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| Edition: | Third edition. |
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- Front Cover; Clinical Biochemistry: Metabolic and clinical aspects; Copyright; Contents; Preface; Contributors; Chapter 1: Uses of biochemical data in clinical medicine; Introduction; Specific uses of biochemical tests; Diagnosis; Management; Assessment of disease severity; Prognosis; Monitoring the progression of disease; Screening; Population screening; Selective screening; Individual screening; Other uses of biochemical investigations; Conclusion; Further reading; Chapter 2: Acquisition and interpretation of biochemical data; Introduction; The Test Request; Factors Affecting Test Results.
- Preanalytical factorsTechnical factors; Biological factors; Endogenous factors; Age; Sex; Ethnic origin; Body mass; Exogenous factors; Time-dependent changes; Stress; Posture; Food intake; Drugs; Other factors; Intrinsic biological variation; Analytical range; Accuracy and bias; Analytical factors; Precision; Specificity and interference; Practicalities: what is desirable performance?; Analytical goals; Postanalytical factors; Interpretation of Results; Normal and abnormal; The meaning of normal; Reference values; Problems with reference intervals.
- Comparison of observed results with reference limitsComparison of results with previous values; The Predictive Value of Tests; Introduction; Definitions; Example; Prevalence and predictive value; Practical applications of the predictive value model; Receiver operating characteristic curves; Likelihood ratios; Conclusion; Acknowledgement; Further reading; Chapter 3: Quality aspects of laboratory medicine; Introduction; What is quality?; Quality standards; Quality assurance; Regulation of laboratories; Quality management systems; Personnel; Premises and environment; Information systems.
- Evaluation and auditClinical quality indicators; Clinical effectiveness; Key performance indicators; Demand management; Evidence-based clinical biochemistry; Point-of-care testing; Conclusion; Further Reading; Chapter 4: Sodium, water and potassium; Physiology; Introduction; Extracellular fluid and sodium; Renal control of sodium output; Intrinsic renal control of tubular reabsorption of sodium; Renin-angiotensin-aldosterone axis; Natriuretic peptides; Sodium appetite; Intracellular fluid and water; Control of renal water output; Osmoregulation; Non-osmotic control of arginine vasopressin.
- Renal responsiveness to arginine vasopressinControl of water intake; Osmoregulation; Non-osmotic control of thirst; Extracellular fluid, intracellular fluid and potassium; Extracellular and intracellular fluid distribution of potassium; Renal control of potassium output; Intrinsic tubular control; Aldosterone; Disorders of sodium metabolism; Sodium deficiency; Clinical presentation; Causes of sodium deficiency; Extrarenal sodium loss; Primary renal sodium loss; Secondary renal sodium loss; Laboratory investigation of sodium deficiency; Management of sodium deficiency; Sodium excess.