http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
1 online resource (230 pages) : illustrations
Adverse Reactions to Drugs, Second Edition focuses on the problems posed by the adverse responses to drugs, as well as drug interactions, dosage, and drug metabolism. The publication first tackles adverse reactions and factors which predispose to adverse drug reactions. Topics include dose adjustment, overdose, renal failure, cumulation, side effects, drug allergy, cumulative overdose, and delayed effects. The text then ponders on drug interactions, including renal excretion, drug metabolism, mutual toxicity, and interactions affecting transport to site of action. The manuscript examines adver.
""Front Cover""; ""Adverse Reactions to Drugs""; ""Copyright Page""; ""Table of Contents""; ""PREFACE TO THE SECOND EDITION""; ""ACKNOWLEDGMENTS""; ""CHAPTER I. THE DAWN OF CONCERN""; ""CHAPTER II. ADVERSE REACTIONS""; ""Dose Related Adverse Reactions to Drugs""; ""Side effects""; ""Secondary effects""; ""Idiosyncrasy""; ""Drug allergy""; ""Long-term Effects""; ""Cumulative overdose""; ""Delayed effects""; ""Conclusion""; ""CHAPTER III. IFACTORS WHICH PREDISPOSE TO ADVERSE DRUG REACTIONS""; ""Overdose""; ""Error""; ""Dose adjustment""; ""Cumulation""; ""Relative Overdose""; ""Liver disease""
""Renal failure""""Other diseases""; ""Genetic variation""; ""CHAPTER IV. DRUG INTERACTIONS""; ""Outside the Body""; ""Interactions affecting Transport to Site of Action""; ""Intracellular transport""; ""Renal excretion""; ""Drug metabolism""; ""Competition at specific receptor sites""; ""Mutual Toxicity""; ""Conclusion""; ""CHAPTER V. ADVERSE REACTIONS IN DENTAL PRACTICE""; ""Drugs used in Dental Practice""; ""Local anaesthetics""; ""Drug Therapy which may be a Hazard in Dental Surgery""; ""Oral anti-diabetic drugs""; ""Cytotoxic drugs and immunosuppressants""
""CHAPTER VI. DRUGS USED IN PREGNANCY,THE NEONATE AND LACTATION""""Pregnancy""; ""First trimester""; ""Second and third trimester""; ""Kernicterus""; ""Haemolytic anaemia and methaemoglobinaemia""; ""Haemorrhage""; ""Chloramphenicol""; ""Oxygen toxicity""; ""Drugs and Lactation""; ""CHAPTER VII. PROBLEMS FOR THE PHARMACEUTICAL INDUSTRY BEFORE MARKETING A NEW DRUG""; ""Animal Studies""; ""Human Studies""; ""Later studies in man""; ""Ethical problems of drug studies in man""; ""The Supervision of Studies in Animals and Man""
""CHAPTER VIII. MONITORING ADVERSE REACTIONS TODRUGS AND THE THERAPEUTIC AUDIT""""The purpose of monitoring""; ""Spontaneous monitoring systems""; ""Intensive surveillance""; ""Record linkage""; ""International cooperation""; ""The need for a therapeutic audit""; ""Diiferences between doctors""; ""Changes of prescribing with time""; ""Geographical differences in prescribing""; ""International differences in prescribing""; ""CHAPTER IX. DRUG REGULATORY BODIES AND THEIR PROBLEMS""; ""The Philosophy of Drug Regulatory Bodies""; ""Features of Some National Drug Regulatory Bodies""
""The Problems of Drug Regulatory Bodies""""Inhibition of innovation""; ""The glare of publicity""; ""Limitations""; ""CHAPTER X. THE FUTURE""; ""1. New developments in the assessment of drugs""; ""2. Operational research""; ""3. Improvement in the accessibility of information on drugs""; ""4. Regulatory bodies""; ""5. Changes in the law""; ""6. Changes in attitudes""; ""APPENDIX I: ADVERSE REACTIONS TO DRUGS""; ""ALIMENTARY SYSTEM""; ""CARDIOVASCULAR SYSTEM""; ""ANTIHYPERTENSIVE DRUGS""; ""RESPIRATORY SYSTEM""; ""NERVOUS SYSTEM""; ""GENITAL SYSTEM""; ""INFECTIONS""; ""ANTIBACTERIAL DRUGS""
Includes bibliographical references (pages 201-207) and index.
Drug-Related Side Effects and Adverse Reactions