rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Mesenchymal stem cells and skeletal regeneration
  name:
    name part: Jones, Elena.
  name:
    name part: ScienceDirect (Online service)
  type of resource: text
  genre: bibliography
  genre: Electronic books.
  origin info:
    place:
      place term: ne
    place:
      place term: Amsterdam
    place:
      place term: Boston
    publisher: Academic Press
    date issued: ©2013
    date issued: 2013
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource
  abstract: This book covers our current understanding of the role of mesenchymal stem cells (MSCs) and other mesenchymal progenitors in skeletal regeneration, encompassing bone, cartilage and whole joint regeneration. The expansion reflects developments in the field to include data on the use of MSCs in drug development, growth factors, scaffolds and biomechanical manipulations for skeletal trauma and diseases, including osteoporosis and arthritis. Written for an audience of clinicians and young researchers who are exposed to MSCs in their work, this work summarizes recent findings pertaining to the definition and characterization of MSCs in skeletal tissues and discusses the mechanisms of their actions in regeneration of bone in vivo. The authors describe recent findings pertaining to the efficacy of MSC therapies in animal models and in human clinical trials and bring together literature showing that the ways MSCs are extracted, expanded and implanted can considerably affect bone formation outcomes. Finally, it presents the latest knowledge on the nature of native MSCs in skeletal tissues, which provide a platform for novel in situ tissue regeneration approaches for systemic bone disease such as osteoporosis. Focuses specifically on the use of stem cells in skeletal tissue generation for a broad audience of stem cell, cancer, and bone biologists, orthopedists, oncologists, and regenerative medicine specialistsProvides a short historical 'detour' and foundational information on founding concepts, discoveries and personalities in MSC researchAssists a new generation of scientists and clinicians in digesting the multitude of journal articles on the topic by providing easily-absorbed and condensed foundational context.
  table of contents: Front Cover; Mesenchymal Stem Cells and Skeletal Regeneration; Copyright Page; Contents; 1 Current Strategies for Skeletal Regeneration in the Early Twenty-First Century; 1.1 The Economic and Social Burden of Diseases Affecting Bone and Cartilage; 1.2 Current Clinical Approaches for Bone Regeneration: The Diamond Concept; 2 Mesenchymal Stem Cells: Discovery in Bone Marrow and Beyond; 2.1 Discovery; 2.2 "Explosion" of Interest in MSCs; 2.3 MSC Tissue Heterogeneity; 3 Traditional Bone Tissue Engineering Using MSCs; 3.1 Proof-of-Principle Experiments in Animal Models; 3.2 Cell Therapy Using MSCs
  table of contents: 3.3 Bone Tissue Engineering3.4 Serum-Free MSC Expansion; 3.5 Osteochondral Tissue Repair; 4 Challenges for Cartilage Regeneration; 4.1 Osteoarthritis (OA) Development and the Loss of Cartilage; 4.2 Current Cartilage Repair Strategies; 4.3 Spontaneous Cartilage Repair; 4.4 Harnessing the Potential of Synovial Fluid MSCs for Cartilage Repair Applications; 5 Animal Models for Investigating MSC Involvement in Bone and Cartilage Repair; 5.1 Small Animal Models; 5.2 Large Animal Models for Bone Repair and Regeneration; 5.3 Animal Models for Osteochondral Tissue Engineering
  table of contents: 5.4 Animal Models for Cartilage Tissue Engineering6 Native MSCs; 6.1 MSCs and Marrow Reticular Cells; 6.2 Nonadherent MSCs; 6.3 Solid Tissues: MSCs and Fibroblasts; 6.4 MSC as a Pericyte; 7 "Trophic" Actions of MSCs; 7.1 Discovery of the Trophic Action of MSCs in Cardiac Repair Trials; 7.2 Other Disease Applications; 8 Novel Approaches for Bone Regeneration Targeting Native MSCs; 8.1 Medical Devices Allowing MSC Concentration; 8.2 Host MSC "Modifiers"; 8.3 "In vivo" Bioreactors and Periosteum-Like Membranes; 8.4 Targeting MSCs in Systemic Bone Diseases: Novel Bone Anabolics
  note: Elena A. Jones [and others].
  note: Includes bibliographical references.
  subject:
    topic: Mesenchymal stem cells
  subject:
    topic: Bone regeneration
  subject:
    topic: Tissue engineering
  subject:
    topic: Mesenchymal Stem Cells
  subject:
    topic: Bone Regeneration
  subject:
    topic: Tissue Engineering
  subject:
    topic: Cellules souches mésenchymateuses
  subject:
    topic: Os
    topic: Régénération
  subject:
    topic: Génie tissulaire
  subject:
    topic: Tissue engineering
  subject:
    topic: Bone regeneration
  subject:
    topic: Mesenchymal stem cells
  classification: QH588.S83 M47 2013
  classification: 616.02/774
  related item:
    title info:
      title: Mesenchymal stem cells and skeletal regeneration
    origin info:
      publisher: Amsterdam ; Boston : Academic Press, ©2013
    identifier: (DLC) 2013427134
  identifier: 9780124079151
  identifier: 0124079156
  identifier: http://proxy.library.tamu.edu/login
  record info:
    record content source: OPELS
    record creation date: 130322
    record change date: 20260326194127.8
    record identifier: in00005751752
    language of cataloging:
      language term: eng