rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Ligand efficiency indices for drug discovery
    sub title: towards an atlas-guided paradigm
  name:
    name part: Abad Zapatero, Celerino.
    role:
      role term: creator
  name:
    name part: ScienceDirect (Online service)
  type of resource: text
  genre: bibliography
  genre: Electronic books.
  origin info:
    place:
      place term: enk
    place:
      place term: Oxford
    publisher: Elsevier
    date issued: 2013
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource (xix, 158 pages) : illustrations (some color)
  abstract: The purpose of Ligand Efficiency Indices for Drug Discovery: Towards an Atlas-Guided Paradigm is to introduce in a concise and self-contained form the concepts, ideas, applications and examples of efficiency-driven drug discovery to the biomedical community at large. The book emphasizes the use of 'new variables' and more objective numerical methods to drive drug discovery in an encompassing way. These 'new variables' are based on Ligand Efficiency Indices (LEIs) formulated in a way that permits mapping Chemico-Biological Space (CBS) in an Atlas-like representation. It provides a practical and timely discussion of the concepts, ideas, applications and examples of efficiency-driven drug discovery. This book emphasizes the use of a graphical representation and objective numerical methods to drive drug discovery more effectively. It presents the definition of LEIs and the corresponding efficiency planes within an atlas-like environment to provide a robust graphical and numerical framework for medicinal chemists and drug-discoverers. Provides a practical and timely discussion of the concepts, ideas, applications and examples of efficiency-driven drug discoveryEmphasizes the use of 'new variables' and more objective numerical methods to drive quicker and more effective drug discoveryPresents the definition of Ligand Efficiency Indices (LEIs) and the corresponding efficiency planes as key concepts to provide a graphical and numerical framework.
  table of contents: pt. I. The elements : data, variables, concept, and the server -- pt. II. Conceptual applications of the atlasCBS : a new paradigm -- pt. III. Exploring CBS : practical examples using the atlasCBS server.
  note: Celerino Abad-Zapatero.
  note: Includes bibliographical references.
  note: English.
  subject:
    topic: Drug development
  subject:
    topic: Structure-activity relationships (Biochemistry)
  subject:
    topic: Pharmaceutical chemistry
  subject:
    topic: Metabolism
  subject:
    topic: Chemistry
  subject:
    topic: Pharmacology
  subject:
    topic: Physical sciences
  subject:
    topic: Life sciences
  subject:
    topic: Carrier proteins
  subject:
    topic: QSAR (Biochemistry)
  subject:
    topic: Ligands
  subject:
    topic: Structure-Activity Relationship
  subject:
    topic: Chemistry, Pharmaceutical
  subject:
    topic: Biochemical Phenomena
  subject:
    topic: Investigative Techniques
  subject:
    topic: Metabolism
  subject:
    topic: Laboratory Chemicals
  subject:
    topic: Chemistry
  subject:
    topic: Specialty Uses of Chemicals
  subject:
    topic: Chemical Phenomena
  subject:
    topic: Analytical, Diagnostic and Therapeutic Techniques and Equipment
  subject:
    topic: Pharmacological Phenomena
  subject:
    topic: Pharmacology
  subject:
    topic: Physiological Phenomena
  subject:
    topic: Chemical Actions and Uses
  subject:
    topic: Phenomena and Processes
  subject:
    topic: Natural Science Disciplines
  subject:
    topic: Biological Science Disciplines
  subject:
    topic: Disciplines and Occupations
  subject:
    topic: Chemicals and Drugs
  subject:
    topic: Carrier Proteins
  subject:
    topic: Drug Discovery
  subject:
    topic: Quantitative Structure-Activity Relationship
  subject:
    topic: Ligands
  subject:
    topic: Médicaments
    topic: Développement
  subject:
    topic: Relations structure-activité (Biochimie)
  subject:
    topic: Chimie pharmaceutique
  subject:
    topic: Métabolisme
  subject:
    topic: Chimie
  subject:
    topic: Pharmacologie
  subject:
    topic: Sciences physiques
  subject:
    topic: Sciences de la vie
  subject:
    topic: Protéines de liaison
  subject:
    topic: Relations structure-activité quantitatives (Biochimie)
  subject:
    topic: Ligands
  subject:
    topic: metabolism (biological concept)
  subject:
    topic: chemistry
  subject:
    topic: pharmacology
  subject:
    topic: physical sciences
  subject:
    topic: biological sciences
  subject:
    topic: MEDICAL
    topic: Drug Guides
  subject:
    topic: MEDICAL
    topic: Nursing
    topic: Pharmacology
  subject:
    topic: MEDICAL
    topic: Pharmacology
  subject:
    topic: MEDICAL
    topic: Pharmacy
  subject:
    topic: Structure-activity relationships (Biochemistry)
  subject:
    topic: QSAR (Biochemistry)
  subject:
    topic: Physical sciences
  classification: RM301.25 .A23 2013eb
  classification: 615.19
  classification: QV 745
  identifier: 9780124046825
  identifier: 0124046827
  identifier: 9780124046351
  identifier: 0124046355
  identifier: http://proxy.library.tamu.edu/login

topic: Pharmacology

topic: Pharmaceutical chemistry

topic: Metabolism

topic: Ligands

topic: Life sciences

topic: Chemistry

topic: Carrier proteins

topic: Drug development

title info:
  title: Ligand Efficiency Indices for Drug Discovery : Towards an Atlas-Guided Paradigm
name:
  name part: Abad-Zapatero, Celerino.
origin info:
  publisher: Burlington : Elsevier Science, ©2013

record content source: E7B
record creation date: 130207
record change date: 20260326193934.0
record identifier: in00005751645
language of cataloging:
  language term: eng