http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
1 online resource (xiii, 611 pages) : illustrations (some color)
In this book, Professor Victor Dubowitz manages to bridge the gap between clinical syndromes/disorders and their underlying pathologies. An internationally renowned figure in the field of muscle disease, Professor Dubowitz skillfully guides you through the complexities of pathologic diagnoses and their implications for clinical treatment. This reference describes the techniques of obtaining a muscle biopsy and examines the histochemical, histological, electron microscopical and molecular appearance of normal muscle and the pathology of individual muscle disease. Covers the entire range of diagnostic/investigative techniques, providing you with all of the necessary tools to formulate an accurate diagnosis. Offers a combination of clinical and pathological experience for a unique perspective on a complex and difficult area of diagnosis. Addresses the "knowledge explosion" over the last 10 years in the fields of molecular genetics and immunocytochemistry, including all of the latest clinically relevant investigative techniques. Focuses on diagnostic techniques and on the diagnostic interpretation of results, giving you a portable reference book and a bench book in a single volume.
Sect. 1. biopsy : normal and diseased muscle -- 1. procedure of muscle biopsy -- 2. Histological and histochemical stains and reactions -- 3. Normal muscle -- 4. Definition of pathological changes seen in muscle biopsies -- 5. Ultrastructural changes in diseased muscle -- 6. Immunohistochemistry -- 7. How to read a biopsy -- Sect. 2. Pathological muscle : individual diseases -- 8. Classification of neuromuscular disorders -- 9. Neurogenic disorders -- 10. Muscular dystrophies and allied disorders I : Duchenne and Becker muscular dystrophy -- 11. Muscular dystrophies and allied disorders II : limb-girdle muscular dystrophies -- 12. Muscular dystrophies and allied disorders III : congenital muscular dystrophies -- 13. Muscular dystrophies and allied disorders IV : Emery Dreifuss muscular dystrophies and Bethlem myopathy -- 14. Muscular dystrophies and allied disorders V : facioscapulohumeral, myotonic and oculopharyngeal muscular dystrophy -- 15. Congenital myopathies -- 16. Myofibrillar myopathies -- 17. Metabolic myopathies I : glycogenoses -- 18. Metabolic myopathies II : lipid related disorders and mitochondrial myopathies -- 19. Endocrine disorders -- 20. Ion channel disorders -- 21. Myasthenic syndromes -- 22. Inflammatory myopathies -- 23. Toxic and drug-induced
Victor Dubowitz, Caroline A. Sewry ; with a contribution on toxic and drug-induced myopathies by Russell Lane.
Includes bibliographical references (pages 557-594).