rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Mechanisms of DNA Repair
  name:
    name part: Doetsch, Paul.
    role:
      role term: edt
  name:
    name part: ScienceDirect (Online service)
  type of resource: text
  genre: Electronic books.
  origin info:
    place:
      place term: xx
    publisher: Elsevier Science & Technology
    date issued: 2012
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource (353 pages)
  abstract: Mechanisms of DNA Repair.
  table of contents: Front Cover; Mechanisms of DNA Repair; Copyright; Contents; Contributors; Preface; Chpater 1: Dynamics of Lesion Processing by Bacterial Nucleotide Excision Repair Proteins; I. Structural Insights of Bacterial Nucleotide Excision Repair; A. Overview of the Process; B. Dynamics of the UvrA2B2-DNA Complex; C. Kinetic Proofreading as Part of a Dynamic DNA Damage Recognition Process: Role of ATP; II. So Few DNA Repair Proteins, So Much DNA: Defining the Big Problem; A. Challenge of Repair Inside a Bacterial Cell; B. Potential Modes of Damage Site Location
  table of contents: C. Necessary Experimental Components to Observe Single Molecules in ActionIII. Damage Searching by UvrA2 and UvrA2B2; IV. Future Directions; A. Observing Protein Nanomachines at Work; B. Overcoming the Brownian Motion Barrier; References; Chpater 2: Transcription-Coupled DNA Repair in Prokaryotes; I. Introduction; II. Background: Genomic Heterogeneity in NER and the Discovery of TCR; III. The Role of RNA Polymerase in TCR; IV. The Role of Mfd in TCR; V. The Role of UvrA in TCR; VI. The Role of UvrB in TCR; VII. Other Examples of Transcription-Related DNA Damage Processing in Bacteria; A. NusA
  table of contents: B. Base Excision RepairVIII. Conclusions; Acknowledgments; References; Chpater 3: The Functions of MutL in Mismatch Repair: The Power of Multitasking; I. Overview of DNA Mismatch Repair; A. DNA Mismatch Repair in Escherichia coli; B. Strand Discrimination in Mismatch Repair in Organisms Lacking MutH; C. The Multiple Faces of MutL; II. MutL is a Multidomain Protein; A. The ATPase Domain; B. DNA Binding; C. The Dimerization Domain; III. Architecture of the Endonuclease Domain; A. The Endonuclease Site; B. MutL is an Mn2+-Dependent Endonuclease; C. The Regulatory Zn2+-Binding Site
  table of contents: D. The Endonuclease Activity of MutLIV. Regulation of the Endonuclease Activity of MutL; A. DNA Binding; B. Stimulatory Effect of the Processivity Clamp; C. Mismatch Dependency; V. Concluding Remarks; References; Chpater 4: The Fpg/Nei Family of DNA Glycosylases: Substrates, Structures, and Search for Damage; I. Introduction; II. Fpg/Nei Phylogeny; III. Fpg/Nei Structures; A. Introduction; B. Substrate Preference; C. Comparison of Structures of the Fpg/Nei Family; IV. Glycosylases Search for Lesions; V. Concluding Remarks; Acknowledgments; References
  table of contents: Chpater 5: Regulation of Base Excision Repair in Eukaryotes by Dynamic Localization StrategiesI. Base Excision Repair; A. Requirements and Limitations of Base Excision Repair; B. Regulation of BER: Current Concepts and Observations; C. Dynamic Localization; II. Dynamic Localization of BER Proteins; A. General Pathway; B. Requirements to Dynamically Localize; C. Examples of Dynamic Localization in Response to Genotoxic Stress; D. Insight into Dynamic Localization; III. Hypotheses on the Orchestration of Dynamic Localization; References
  subject:
    topic: DNA repair
  subject:
    topic: DNA Repair
  subject:
    topic: ADN
    topic: Réparation
  subject:
    topic: Genetics & Genomics
  subject:
    topic: Internal Medicine
  subject:
    topic: MEDICAL
  subject:
    topic: Genetics
  subject:
    topic: Life Sciences
  subject:
    topic: SCIENCE
  subject:
    topic: DNA repair
  classification: QP624
  classification: 616.042
  related item:
    title info:
      title: Progress in Molecular Biology and Translational Science Ser. ; Vol. 110
  identifier: 1280848200
  identifier: 9781280848209
  identifier: 9780123876669
  identifier: 0123876664
  identifier: 9780123876652
  identifier: 0123876656 (Trade Cloth)
  identifier: 0123876656
  identifier: 00991439
  identifier: http://proxy.library.tamu.edu/login
  record info:
    record content source: IDEBK
    record creation date: 120702
    record change date: 20260326192532.0
    record identifier: in00005750253
    language of cataloging:
      language term: eng