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Freeze-drying of pharmaceutical and food products
Freeze-drying is an important preservation technique for heat-sensitive pharmaceuticals and foods. Products are first frozen, then dried in a vacuum at low temperature by sublimation and desorption, rather than by the application of heat. This text addresses both principles and practice in this area. Freeze-drying is an important preservation technique for heat-sensitive pharmaceuticals and foods. Products are first frozen, then dried in a vacuum at low temperature by sublimation and desorption, rather than by the application of heat. The resulting items can be stored at room temperature for long periods. This informative text addresses both principles and practice in this area. The first chapter introduces freeze-drying. The authors then review the fundamentals of the technique, heat-mass transfer analyses, modelling of the drying process and the equipment employed. Further chapters focus on freeze-drying of food, freeze-drying of pharmaceuticals and the protective agents and additives applied. The final chapter covers the important subjects of disinfection, sterilization and process validation. Freeze-drying of pharmaceutical and food products is an essential reference for food, pharmaceutical and refrigeration engineers and scientists with an interest in preservation techniques. It will also be of use to students in these fields.
Introduction-- Fundamentals of freeze drying-- Heat-mass transfer analyses and modeling for drying process-- Equipment of freeze drying-- Freeze drying of food-- Protective agent and additives for freeze-drying of pharmaceutical products-- Freeze drying of pharmaceuticals-- Disinfection, sterilization and valiation in freeze drying.
T-DC Hua ; Guest editor B.-L. Liu, H. Zhang.
Tse-Chao Hua and Bao-Lin Liu have studied in both China and the USA and are currently faculty members at Shanghai University of Science and Technology. Dr Hua has studied preservation technology since 1980. His interests include cryopreservation of cells and tissues, cold storage and freeze-drying of food, pharmaceuticals and living cells. Dr Liu has worked on cryobiology since 1993. He is interested in vitrification, biomedical engineering and freeze-drying technology. Dr Zhang has studied in China and Germany with a particular focus on refrigeration and cryogenics."
Woodhead Publishing in food science, technology, and nutrition ; 198