The Proteasomal System in Aging and Disease /
This volume of Progress in Molecular Biology and Translational Science discusses cutting-edge research of proteasomes and proteasome-associated proteins and cellular systems. The volume is split into two sections. The first part discusses the current knowledge of the structure, function, and regulat...
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| Format: | eBook |
| Language: | English |
| Language Notes: | Text in English. |
| Published: |
Amsterdam ; Boston, MA :
Elsevier/Amsterdam Press,
2012.
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| Series: | Progress in molecular biology and translational science ;
v. 109. |
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- III. ConclusionReferences; Chapter 3: Immunoproteasomes: Structure, Function, andAntigen Presentation; I. Introduction; II. Immunoproteasome Structure; III. Regulation of Gene Expression; IV. Assembly of the 20S Core; V. Enzymatic Activity; VI. Immunoproteasome Knockout Mice; VII. Immunoproteasome Function; A. Antigen Processing and the Immune Response; B. Nonimmune Roles for I-proteasome; VIII. Mutations and Linkage to Human Disease; References; Chapter 4: Interactions of the Proteasomal System with Chaperones: Protein Triage and ProteinQuality control; I. Introduction
- II. Cytosolic Chaperones: The Hsp FamilyA. High-Molecular-Weight Hsps; 1. Hsp100; 2. Hsp90; 3. Hsp70; 4. Hsp40; B. Small Hsps: Hsp27; C. Regulation of Hsps; III. Refolding or Degradation?; A. BAG-1 and CHIP Inhibition of Chaperones and Promotion of Proteasomal Degradation; B. Hip and Hop: Stabilizing the Refolding Process; C. The Co-chaperone-Independent Decision of Folding or Degradation by sHsps; IV. Heat Shock Response After Proteasome Inhibition; A. Regulation of Classical Hsps After Proteasome Inhibition; B. Regulation of Heme Oxygenase-1 After Proteasome Inhibition
- V. Inhibition of Hsps: Influence on Proteasomal DegradationVI. Hsps and the Proteasomal System During Oxidative Stress and the Aging Process; VII. Neurodegenerative Diseases: Connection to the Hsp Family and the Proteasome; A. Alzheimer Disease; B. Parkinson Disease; VIII. Early-Stage Protein Quality Control and ERAD; A. Yeast: ERAD-L; B. Yeast: ERAD-M/C; C. The Mammalian ERAD Process; D. The ERAD Pathway of Non-glycosylated Proteins; E. Proteasome Inhibition and Its Influence on ER Stress and the Unfolded Protein Response; IX. Conclusion; References; Chapter 5: Proteasome Inhibitors