rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Current concepts in drug metabolism and toxicology
  name:
    name part: Hawksworth, Gabrielle M.
  name:
    name part: ScienceDirect (Online service)
  type of resource: text
  genre: bibliography
  genre: Electronic books.
  origin info:
    place:
      place term: ne
    place:
      place term: Amsterdam
    place:
      place term: Boston
    publisher: Elsevier/Academic Press
    date issued: 2012
    edition: 1st ed.
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource (xi, 287 pages :) : illustrations (some color).
  abstract: This new volume of Advances in Pharmacology explores the current concepts in drug metabolism and toxicology. Chapters cover the Keap1-Nrf2 cell defence pathway, Animal models of drug-induced idiosyncratic toxicity and the use of human embryonic and induced pluripotent stem cells for modelling metabolism and toxicity. With a variety of chapters and the best authors in teh field, the volume is an essential resource for Pharmacologists, Immunologists and Biochemists alike. Explores the current concepts in drug metabolism and toxicology Chapters cover such areas as the Keap1-Nrf2 cell defense pathway, animal models of drug-induced idiosyncratic toxicity and the use of human embryonic and induced pluripotent stem cells for modeling metabolism and toxicityAn essential resource for pharmacologists, immunologists and biochemists alike.
  table of contents: Front Cover; Current Concepts Indrug Metabolismand Toxicology; Copyright; Contents; Contributors; Membrane Transporters in Drug Development; Abstract; I. Introduction; II. Key Features of Transporters; III. Transporters and the Pharmaceutical Industry; IV. Studying and Contextualizing Transporter Interactions: Application and Interpretation of Data; VI. Conclusion; Acknowledgments; Abbreviations; References; The Keap1-Nrf2 Cell Defense Pathway -- A Promising Therapeutic Target?; Abstract; I. Introduction; II. The Keap1-Nrf2 Cell Defense Pathway
  table of contents: III. Activation of Nrf2 as a Potential Therapeutic StrategyIV. Inhibition of Nrf2 as a Potential Therapeutic Strategy; V. Conclusion; Acknowledgments; Abbreviations; References; Animal Models of Idiosyncratic Drug Reactions; Abstract; I. Introduction; II. Animal Models of Skin Rash; III. Animal Models of Liver Toxicity; IV. Animal Models of Hematological Toxicity; V. Animal Models of Generalized Hypersensitivity Reactions; VI. Animal Models of Generalized Autoimmunity; VII. Conclusion; Acknowledgments; Abbreviations; References
  table of contents: Genetic Polymorphisms Affecting Drug Metabolism: Recent Advances and Clinical AspectsAbstract; I. Introduction; II. Recent Advances in the Pharmacogenetics of Cytochromes P450; III. Recent Advances in the Pharmacogenetics of Non-P450 Metabolism; IV. Clinical Relevance of Polymorphic Metabolism -- Some Contemporary Examples; V. Conclusion; Abbreviations; References; Arylamine N-Acetyltransferases -- from Drug Metabolism and Pharmacogenetics to Identification of Novel Targets for Pharmacological Intervention; Abstract; I. Introduction; II. NAT Enzyme Mechanism; III. NAT Genes and Pharmacogenetics
  table of contents: IV. The Genomic Distribution and Function of NATsV. NAT Gene Expression and Regulation; VI. Development of NAT Inhibitors; VII. Conclusion; Acknowledgments; Abbreviations; References; Human Pluripotent Stem Cells for Modeling Toxicity; Abstract; I. Introduction; II. The Use of Human Stem Cells in Developmental Toxicity; III. The Use of Human Stem Cells in Cardiotoxicity; IV. The Use of Human Stem Cells in Hepatotoxicity; V. The Use of Human Stem Cells in Neurotoxicity; VI. Conclusion; Abbreviations; References; Disposition of Biologics; Abstract; I. Introduction; II. Routes of Administration
  table of contents: III. Mechanisms of Biologics Distribution and Clearance, The Importance of Active ProcessesIV. Distribution Studies with Biologics and Relevance to Toxicology Studies; V. Metabolism of Biologics; VI. Consideration of Immunogenicity -- Changes in Disposition and Impact on Toxicology; VII. Conclusion; References; Index; Recent Volumes in the Serial
  note: edited by Gabrielle M. Hawksworth.
  note: Includes bibliographical references and index.
  note: English.
  subject:
    topic: Drugs
    topic: Metabolism
  subject:
    topic: Toxicology
  subject:
    topic: Drugs
    topic: Side effects
  subject:
    topic: Drug-Related Side Effects and Adverse Reactions
  subject:
    topic: Pharmaceutical Preparations
    topic: metabolism
  subject:
    topic: Toxicology
  subject:
    topic: Médicaments
    topic: Métabolisme
  subject:
    topic: Toxicologie
  subject:
    topic: Médicaments
    topic: Effets secondaires
  subject:
    topic: toxicology
  subject:
    topic: MEDICAL
    topic: Pharmacology
  subject:
    topic: Drugs
    topic: Side effects
  subject:
    topic: Drugs
    topic: Metabolism
  subject:
    topic: Toxicology
  subject:
    topic: Medical toxicology
  subject:
    topic: Pharmacology
  subject:
    topic: Health and Wellbeing
  classification: RM301.55 .C87 2012eb
  classification: 615.704
  related item:
    title info:
      title: Advances in pharmacology (San Diego, Calif.) ; 63
  identifier: 9780123983596
  identifier: 0123983592
  identifier: 9780123983398
  identifier: 1280779292
  identifier: 9781280779299
  identifier: 9786613689689
  identifier: 6613689688
  identifier: 0123983398
  identifier: 2013405081
  identifier: Title purchased via Dawsonera PDA
  identifier: http://proxy.library.tamu.edu/login
  record info:
    record content source: E7B
    record creation date: 120711
    record change date: 20260326192521.0
    record identifier: in00005750135
    language of cataloging:
      language term: eng