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Amiloride-sensitive sodium channels: physiology and functional diversity
1 online resource (xiii, 384 pages) : illustrations.
Sodium reabsorbing epithelia play a major role in whole-body sodium homeostasis. Some examples of sodium regulating tissues include kidney, colon, lung, and sweat ducts. Sodium transport across these membranes is a two-step process: entry through an amiloride-sensitive sodium channel and exit via the ouabain-sensitive sodium/potassium ATPase. The sodium entry channels are the rate-limiting determinant for transport and are regulated by several different hormones. The sodium channels also play a significant role in a number of disease states, like hypertension, edema, drug-induced hyperkalemia, and cystic fibrosis. Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity provides the first in-depth exchange of ideas concerning these sodium channels, their regulation and involvement in normal and pathophysiological situations. Key Features * Summarizes current state of amiloride-sensitive sodium channel field * Analyzes structure-function of epithelial sodium channels * Discusses immunolocalization of epithelial sodium channels * Examines hormonal regulation of sodium channels * Discusses sodium channels in lymphocytes, kidney, and lung * Considers mechanosensitivity of sodium channels * Provides ideas on sodium channels and disease.
Chapter 4. Cell-Specific Expression of ENaC and Its Regulation by Aldosterone and Vasopressin in Kidney and ColonI. Introduction; II. Cell-Specific Expression; III. Regulation of ENaC Expression by Aldosterone and Vasopressin; References; Chapter 5. Regulation of ENaC by Interacting Proteins and by Ubiquitination; I. Introduction; II. Proline-Rich Regions in ENaC and Their Interacting Proteins; III. Nedd4: Its Domains and Mode of Interaction with ENaC; IV. Regulation of ENaC Stability and Function by Ubiquitination; V. Role of the C2 Domain of Nedd4 in Ca2+-Dependent Membrane Targeting
VI. SummaryReferences; Chapter 6. Role of G Proteins in the Regulation of Apical Membrane Sodium Permeability by Aldosterone in Epithelia; I. Introduction; II. Control of Basal Na+ Transport by G Proteins; III. GTP-Dependent Methylation of Membrane Proteins; IV. Control of Basal Na+ Permeability by Methylation; V. Aldosterone-Dependent Methylation of Membrane Proteins; VI. Aldosterone-Dependent Membrane GTPase Activity; VII. The Effect of Pertussis Toxin on Membrane Na+ Transport and GTPase Activity; VIII. The Effect of Aldosterone on G-Protein Expression; IX. Conclusion; References
Chapter 7. The Role of Posttranslational Modifications of Proteins in the Cellular Mechanism of Action of AldosteroneReferences; Chapter 8. Regulation of Amiloride-Sensitive Na+ Channels in the Renal Collecting Duct; I. Introduction; II. Vasopressin Can Act as an Antinatriuretic as Well as an Antidiuretic Hormone; III. Autacoids That Limit the Actions of Aldosterone and Vasopression in the CCD; IV. Trafficking and the Regulation of the Amiloride-Sensitive Na+ Channel; V. A Challenge for Integrative Physiology-The Link between Na+ Retention and Hypertension; References
Includes bibliographical references and index.