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Human herpesvirus-6: epidemiology, molecular biology and clinical pathology
1 online resource (xxiv, 341 pages) : illustrations (some color).
This publication on HHV-6 is the first and so far only one where a composite picture of the virus is presented. Comprehensive accounts of HHV-6 biology, molecular virology, epidemiology and their association with diseases, including the effects of antiviral drugs, are covered in chapters contributed by leading researchers on HHV-6. The book is an excellent source of reference on HHV-6 for basic researchers, diagnostic virologists, clinicians, medical students and medical librarians since it provides the most current state-of-the-art information on HHV-6.
Front Cover; Human Herpesvirus-6: Epidemiology, molecular biology and clinical pathology; Copyright Page; Contents; Editors' foreword; Preface by Glaser; Preface by Pearson; List of contributors; Part I: General virology; Chapter 1. The discovery of human herpesvirus type 6; 1.1. Introduction; 1.2. Discovery of HHV-6; Chapter 2. The epidemiology of human herpesvirus-6; 2.1. Introduction; 2.2. Methodologic considerations; 2.3. Demographic patterns of virus infection; 2.4. Etiologic implications of clinical studies; 2.5. Discussion; Chapter 3. Target cells for infection; 3.1. Introduction
3.2. Role of cellular activation3.3. CD4+ T lymphocytes; 3.4. CD8+ T lymphocytes; 3.5. B lymphocytes; 3.6. Mononuclear phagocytes; 3.7. Fibroblasts; 3.8. Other cell lineages; 3.9. Established cell lines; 3.10. Nonhuman models; 3.11. Conclusions; Chapter 4. In vitro propagation systems for HHV-6; 4.1. Introduction; 4.2. Propagation and productive infection of HHV-6 in continuous cell lines and primary cells; 4.3. Concluding remarks; Chapter 5. Infection, latency and immortalization of human cells with HHV-6; 5.1. Introduction
5.2. Infection of human T cell lines with HHV-6 isolates and establishment of latency5.3. Immortalization of T lymphocytes with HHV-6; 5.4. Infection of human fibroblasts with HHV-6; 5.5. Conclusions; Chapter 6. Electron microscopy of human herpesvirus-6 (HHV-6); 6.1. Introduction; 6.2. Ultrastructure; 6.3. Virus replication; 6.4. Summary and discussion; Chapter 7. Biology and strain variants; 7.1. History and introduction; 7.2. Comparison of HHV-6 isolates; Chapter 8. Molecular biology of human herpesvirus 6 (HHV-6); 8.1. HHV-6: molecular evidence for a new human herpesvirus
8.2. Molecular heterogeneity of HHV-68.3. General molecular structure of the HHV-6 genome; 8.4. Characterization, cloning and sequencing of HHV-6: homology and colinearity with HCMV; 8.5. Homology between HHV-6 and other viruses: homology between the putative HHV-6 PH protein and the AAV-2 rep gene; 8.6. Molecular interactions between HHV-6 and HIV-1; 8.7. Does HHV-6 have transformating properties?; 8.8. Molecular evidence for HHV-6 in other diseases; 8.9. Human herpesvirus 7 (HHV-7); 8.10. Future prospects; Chapter 9. Proteins of human herpesvirus-6; 9.1. Introduction
9.2. Initial identification of HHV-6 proteins9.3. HHV-6 proteins specific for infected cells recognized by polyclonal rabbit antiodies; 9.4. HHV-6 proteins recognized by human sera; 9.5. HHV-6 glycoproteins recognized by human sera; 9.6. HHV-6 polypeptides associated with infected cell membranes immuno-precipitated by human sera; 9.7. HHV-6 proteins defined by monoclonal antibodies; 9.8. Antigenic variations among HHV-6 strains; 9.9. Conclusions; Chapter 10. Interactions between HHV-6 and other viruses; 10.1. Introduction; 10.2. Interactions between HHV-6 and HIV-I
editors, Dharam V. Ablashi, Gerhard R.F. Krueger, and S. Zaki Salahuddin.
Includes bibliographical references and index.
Perspectives in medical virology. Volume 4, Human herpesvirus-6: epidemiology, molecular biology and clinical pathology