Genetic models of schizophrenia /
This volume focuses on how genetic models for schizophrenia, that is manipulation in genetic susceptibility factors for the disease, have potential in opening a new window of better understanding of etiology-relevant mechanisms. In addition, these models can provide a new platform for drug screening...
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| Format: | eBook |
| Language: | English |
| Published: |
Amsterdam ; Boston :
Elsevier,
2009.
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| Edition: | 1st ed. |
| Series: | Progress in brain research ;
v. 179. |
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
| Summary: | This volume focuses on how genetic models for schizophrenia, that is manipulation in genetic susceptibility factors for the disease, have potential in opening a new window of better understanding of etiology-relevant mechanisms. In addition, these models can provide a new platform for drug screening toward the treatment of the disease. The text systematically introduces the representative models for schizophrenia currently available in mice, including mice with modulation of neurotransmission (glutamate and dopamine receptors, respectively) and key intracellular signaling (Disrupted in Schizophrenia, Dysbindin, and phosphodiesterase) possibly associated with neurotransmission, together with genetic support. It also covers novel techniques to generate mouse models for schizophrenia and refers to the use of drosophila, zebrafish, and primates for modeling the disease, in addition to rodents. |
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| Physical Description: | 1 online resource (x, 130 pages) : illustrations |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: | 9780444534309 044453430X 9780080962238 0080962238 |