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1 online resource (xii, 262 pages) : illustrations
The Quinolones covers reviews on the history, chemistry and mechanism of action, in vitro properties, pharmacokinetics, clinical overview, toxicity, adverse effects and drug interactions, and future prospects of the 4-quinolones. The book discusses the microbiology of quinolones, particularly with consideration of the development of resistance, pharmacology, toxicology, and clinical uses. Chemists, microbiologists, pharmacologists and clinicians will find the book useful.
Front Cover; The Quinolones; Copyright Page; Contributers; Preface; Table of Contents; Chapter 1. The Quinolones: History and Overview; 1.1 Mechanism of action; 1.2 Activity in vitro; 1.3 Bacterial resistance; 1.4 Clinical pharmacology; 1.5 Clinical uses; 1.6 Adverse effects; 1.7 Summary; References; Chapter 2. Chemistry and Mechanisms of Action of the Quinolone Antibacterials; 2.1 Chemistry; 2.2 Target site; 2.3 Selectivity; 2.4 Antibacterial activities; 2.5 4-Quinolone interactions with ions; 2.6 4-Quinolone interactions with oxygen; 2.7 4-Quinolone interactions with other antibacterials.
2.8 ResistanceReferences; Chapter 3. In vitro Properties of the Quinolones; 3.1 Gram-negative aerobes; 3.2 Gram-positive aerobes; 3.3 Anaerobes; 3.4 Miscellaneous organisms; 3.5 Development of resistance; 3.6 Conclusion; References; Chapter 4. Pharmacokinetics of Fluorinated Quinolones; Introduction; 4.1 Serum concentrations; 4.2 Urine concentrations; 4.3 Steady state; 4.4 Pharmacokinetics; 4.5 Elimination; 4.6 Bioavailability; 4.7 Impaired renal function; 4.8 Impaired liver function; 4.9 Impact of food; 4.10 Interactions; 4.11 Influence of disease; 4.12 Extravascular penetration; References.
Chapter 5. Clinical Overview of the Newer 4-Quinolone Antibacterial AgentsIntroduction; 5.1 Urinary tract infections; 5.2 Respiratory tract infections; 5.3 Gastrointestinal infections; 5.4 Skin and soft-tissue infections; 5.5 Osteomyelitis; 5.6 Sexually transmitted diseases; 5.7 Immunocomprised patients; 5.8 Central nervous system infections; 5.9 Other potential uses; 5.10 Summary; References; Chapter 6. Safety Overview: Toxicity, Adverse Effects and Drug Interactions; 6.1 Introduction; 6.2 Toxicity of quinolones; 6.3 Adverse effects of fluoroquinolones in clinical studies.
6.4 Drug interactionsReferences; Chapter 7. The Quinolones: Prospects; 7.1 Microbiology; 7.2 Resistance of bacteria to quinolones; 7.3 Pharmacology; 7.4 Toxicological issues; 7.5 Clinical considerations for future use of quinolones; 7.6 Prophylactic use of quinolones; 7.7 Summary; References; Index.
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL
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Includes bibliographical references and index.
London ; San Diego : Academic Press, 1988