http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
1 online resource (xxv, 432 pages, 10 unnumbered pages of plates) : illustrations
Methods included in this volume apply to the expression and characterization of retroviral proteases and their inhibitor/substrate design.
1. Expression Systems for Retroviral Proteases / Jeffrey Stebbins and Christine Debouck -- 2. Genetic Approaches Designed to Minimize Cytotoxicity of Retroviral Protease / C.J. Rizzo and B.D. Korant -- 3. Host Strain Selection for Bacterial Expression of Toxic Proteins / Elizabeth Chen -- 4. Assay Methods for Retroviral Proteases / Christopher U.T. Hellen -- 5. Analysis of Human Immunodeficiency Virus Type 1 Protease Activity in Eukaryotic and Bacterial Cells / Andrew H. Kaplan, Marianne Manchester, Lorraine Everitt and Ronald Swanstrom -- 6. Synthetic Approaches to Continuous Assays of Retroviral Proteases / Grant A. Krafft and Gary T. Wang -- 7. Identification, Purification, and Cell Culture Assays of Retroviral Proteases / Klaus von der Helm, Sigrio Seelmeier, Alexei Kisselev and Hans Nitschko -- 8. Stability of Dimeric Retroviral Proteases / Paul L. Darke.
9. Use of Steady State Kinetic Methods to Elucidate the Kinetic and Chemical Mechanisms of Retroviral Proteases / Thomas D. Meek, Evelyn J. Rodriguez and Thelma S. Angeles -- 10. X-Ray Structures of Retroviral Proteases and Their Inhibitor-Bound Complexes / Dagmar Ringe -- 11. Probing Structure-Function Relationships in Human Immunodeficiency Virus Type 1 Protease via Molecular Dynamics Simulation / William E. Harte, Jr. and David L. Beveridge -- 12. Relationships of Human Immunodeficiency Virus Protease with Eukaryotic Aspartic Proteases / Xin-Li Lin, Ying-Zhang Lin and Jordan Tang -- 13. Processing of Retroviral Gag Polyproteins: An in Vitro Approach / Carol Carter and Gabriele Zybarth -- 14. Subsite Preferences of Retroviral Proteinases / Ben M. Dunn, Alla Gustchina, Alexander Wlodawer and John Kay -- 15. Specificity of Retroviral Proteases: An Analysis of Viral and Nonviral Protein Substrates / Alfredo G. Tomasselli and Robert L. Heinrikson.
16. Rapid Determination of Endoprotease Specificity Using Peptide Mixtures and Edman Degradation Analysis / Frank R. Masiarz and Bruce A. Malcolm -- 17. Design of Tight-Binding Human Immunodeficiency Virus Type 1 Protease Inhibitors / Joseph P. Vacca -- 18. Design of Symmetry-Based, Peptidomimetic Inhibitors of Human Immunodeficiency Virus Protease / Dale J. Kempf -- 19. Advances in Automated Docking Applied to Human Immunodeficiency Virus Type 1 Protease / Michael D. Miller, Robert P. Sheridan, Simon K. Kearsley and Dennis J. Underwood -- 20. Use of Molecular Dynamics and Free Energy Perturbation Calculations in Anti-Human Immunodeficiency Virus Drug Design / Margaret A. McCarrick and Peter Kollman -- 21. Qualitative Study of Drug Resistance in Retroviral Protease Using Structural Modeling and Site-Directed Mutagenesis / J. Chris Culberson, Bruce L. Bush and Vinod V. Sardana.
edited by Lawrence C. Kuo, Jules A. Shafer.
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL
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Includes bibliographical references and indexes.