Structural genomics. Part A /
Structural genomics is the systematic determination of 3-dimensional structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any prote...
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| Format: | eBook |
| Language: | English |
| Published: |
Oxford ; Burlington, MA :
Academic Press,
2008.
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| Edition: | 1st ed. |
| Series: | Advances in protein chemistry and structural biology ;
v. 75. |
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- Introduction; Analysis of genomes for structural genomics and the limitations of sequence analysis; Structure determination pipeline for structural genomics;Gene cloning and protein expression;Gene cloning and expression of membrane proteins; High-throughput protein purification for x-ray crystallography and NMR; High-throughput protein crystallization; Structure determination using synchrotron radiation; Application of NMR to structural genomics; Development of key high-throughput technologies: High-throughput functional screening; Development of key high-throughput technologies: Structure prediction and homology modeling; Functional inferences from structure; Structural genomics programs (SARS case); Structural genomics programs (E.coli);Structural genomics as a structural foundation for drug discovery; Structural genomics of eukaryote; Structural genomics of complexes; Dissemination structural genomics data to biology community; ;