rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Design and optimization in organic synthesis
  name:
    name part: Carlson, Rolf
    name part: 1946-
    role:
      role term: creator
  name:
    name part: ScienceDirect (Online service)
  type of resource: text
  genre: bibliography
  genre: Electronic books.
  origin info:
    place:
      place term: ne
    place:
      place term: Amsterdam
    place:
      place term: New York
    publisher: Elsevier
    date issued: 1992
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource (xvi, 536 pages) : illustrations
  abstract: This is the first general textbook on experimental design and optimization in organic synthesis. The book presents a unified methodology for carrying out systematic studies when the objective is to develop efficient and optimum synthetic methods. Strategies are included both for exploring the experimental conditions and for systematic studies of entire reaction systems (substrates, reagent(s) and solvents). The methodology is based on multivariate statistical techniques. The following topics are treated in depth: classical two-level designs for screening experiments, gradient methods (steepest ascent, simplex methods) as well as response surface techniques for optimization, principal components analysis and PLS modelling. The book is intended as a hands-on text for chemists and engineers engaged in developing synthetic methods in industrial research, e.g. in fine chemicals and pharmaceuticals production, as well as for advanced undergraduate students, graduate students, and researchers in an academic environment.
  table of contents: Strategies on different levels in organic synthesis -- Experimental study of reaction conditions. Initial remarks -- Models as tools -- General outline for screening experiments -- Two-level factorial designs -- Two-level fractional factorial design -- Other designs for screening experiments -- Summary of screening experiments -- Introduction to optimization -- Steepest ascent -- Simplex methods -- Response surface methods -- Summary of strategies to explore the experimental space -- The reaction space -- Principal properties -- Strategies for the selection of test systems -- Quantitative relations between observed responses and experimental variations -- A method for determining a suitable order of introducing reagents in "one-pot" procedures.
  note: Rolf Carlson.
  note: Includes bibliographical references and index.
  subject:
    topic: Organic compounds
    topic: Synthesis
  subject:
    topic: Composés organiques
    topic: Synthèse
  subject:
    topic: SCIENCE
    topic: Chemistry
    topic: Organic
  subject:
    topic: Organic compounds
    topic: Synthesis
  subject:
    topic: Organic compounds
    topic: Synthesis
  classification: QD262 .C32 1992eb
  classification: 547.2
  classification: 35.52
  classification: a547.2 c20
  related item:
    title info:
      title: Design and optimization in organic synthesis
    name:
      name part: Carlson, Rolf, 1946-
    origin info:
      publisher: Amsterdam ; New York : Elsevier, 1992
    identifier: (DLC) 91036733
    identifier: (OCoLC)24590638
  related item:
    title info:
      title: Data handling in science and technology ; v. 8
  identifier: 9780444892010
  identifier: 044489201X
  identifier: 9780080868356
  identifier: 0080868355
  identifier: 91036733
  identifier: 122014:125513 Elsevier Science & Technology
  identifier: http://proxy.library.tamu.edu/login
  record info:
    record content source: OPELS
    record creation date: 090320
    record change date: 20260326161134.1
    record identifier: in00005736875
    language of cataloging:
      language term: eng