Gap junctions : molecular basis of cell communication in health and disease /
Since the first gap junction protein (connexin) was cloned over a decade ago, more than a dozen connexin genes have been cloned. Consequently, a wealth of information on the molecular basis of gap junctional communication has been accumulated. This book pays tribute to this exciting era in the histo...
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| Format: | eBook |
| Language: | English |
| Language Notes: | English. |
| Published: |
San Diego :
Academic Press,
©2000.
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| Series: | Current topics in membranes ;
v. 49. |
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
Table of Contents:
- Front Cover; Gap Junctions: Molecular Basis of Cell Communication in Health and Disease; Copyright Page; Contents; Contributors; Preface; Previous Volumes in Series; Part I: Channel Structure, Assembly, and Degradation; Chapter 1. Gap Junction Structure: New Structures and New Insights; I. Overview of Gap Junction Structure; II. The Constituent Proteins of Gap Junctions: Size and Topology Models of the Connexin Family; III. Isolation and Purification of Gap Junctions; IV. Molecular Structure of Gap Junctions Determined by X-Ray Diffraction and Electron Microscopy; V. Concluding Remarks.
- II. Homotypic hCx37 and rCx43 Gap Junction ChannelsIII. Hetcrotypic hCx37-rCx43 Gap Junction Channels; IV. Co-transfection of hCx37 and rCx43: Heteromcric Gap Junction Channels; V. Why Would a Cell Bother with Heteromeric Gap Junction Channels?; References; Chapter 4. Heteromultimeric Gap Junction Channels and Cardiac Disease; I. Introduction; II. Gap Junctions: Structure and Nomenclature; III. Endogenous Expression of Multiple Connexins in Various Tissues; IV. Experimental Formation of Heteromultimeric Channels in Exogenous Systems; V. Molecular Regions Involved in Assembly.
- VI. Physiological Implications of Heteromultimeric Channel FormationVII. Conclusions and Future Directions; Rcferences; Chapter 5. Ion Permeation through Connexin Gap Junction Channels: Effects on Conductance and Selectivity; I. Introduction; II. Theories of Electrodiffusion; III. Gap Junction Channel Conductance and Permeability; IV. Summary; References; Chapter 6. Phosphorylation of Connexins: Consequences for Permeability, Conductance, and Kinetics of Gap Junction Channels; I. Introduction; II. Connexin43; III. Connexin40 and -45; IV. Connexin26 and -32; V. Concluding Remarks; References.
- Chapter 7. Intercellular Calcium Wave Communication via Gap Junction-Dependent and -Independent MechanismsI. Introduction; II. Two Routes for Intercellular Calcium Wave Propagation; III. Some Features of Intercellular Ca2+ Waves Depend upon the Initiating Stimulus; IV. Mechanisms for Intercellular Ca2+ Wave Propagation; V. How Connexins Can Potentially Influence and Modulate the Propagation of Intercellular Ca2+ Waves; VI. How the Extracellular Space May Influence Calcium Wave Propagation; VII. Functional Roles of Intercellular Calcium Waves; VIII. Prospects; References.