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Published since 1959, this serial stays up-to-date with current topics in neuroscience; the contributors are first-class experts in their fields. Volume 38 of International Review of Neurobiology presents in-depth reviews on GABAA and other transmitter systems and mechanisms, the genetics of the basal ganglia, the Bergmann glial cell, and the modes of action of monoamines at the cellular level. Neuroscientists will find particularly useful the recent studies on the molecular biology of neurotransmitter transporters. Key Features * Structure, pharmacology, and regulation of GABAA * Bergmann glial cell physiology * Abnormalities of transmitter systems in schizophrenia * Research in genetic influences on the basal ganglia * Presynaptic electrophysiology measurements Monoamines as stimulators and inhibitors of cellular mechanisms * Molecular biology of neurotransmitter transporters.
Fornt Cover; International Review of Neurobiology, Volume 38; Copyright Page; Contents; Chapter 1. Regulation of GABAA Receptor Function and Gene Expression in the Central Nervous System; I. Introduction: The Structure and Function of GABAA/Benzodiazepine Receptors; II. Multiple Mechanisms of GABAA/Benzodiazepine Receptor Regulation; III. Benzodiazepine Regulation of GABAA Receptor Binding and Function; IV. Barbiturate Regulation of GABAA Receptor Function and Expression; V. Ethonol Regulotion of GABAA Receptor Function and Expression; VI. Endogenous Neurosteroid Regulation of GABAA Receptors
VII. Developmental Alterations in GABAA Receptor ExpressionVIII. Alterations in Receptor Subunit Composition: A Novel Mechanism of Regulation of Ligand-Gated Ion Channels; IX. Conclusions: New Breakthroughs, New Questions; References; Chapter 2. Genetics and the Organization of the Basal Ganglia; I. Introduction; II. Genetic Strategies; III. Genetics and Behaviors Related to the Basal Ganglia; IV. Genetics and the Functional Architecture of the Basal Ganglia; V. Conclusions; References; Chapter 3. Structure and Pharmacology of Vertebrate GABAA Receptor Subtypes
I. Introduction to the GABAA ReceptorII. Diversity of the GABAA Receptor Gene Family; III. Phosphorylation of GABAA Receptors; IV. The Composition of GABAA Receptors in Vivo; V. Drug Binding Sites on the GABAA Receptor; VI. Conclusion; References; Chapter 4. Neurotransmitter Transporters: Molecular Biology, Function, and Regulation; I. Introduction; II. Molecular Biology of Transporters; III. Shared Structural Features; IV. Regulation of Transporters; V. Ionic Requirements; VI. Transmitter Efflux; VII. Transporter Localization; VIII. Transporter Heterogeneity; IX. Future Directions
II. A Critical Review of Methods Used for the Analysis of Catecholamines, Indoleamines, Their Metabolites, and Related Enzymes in Biological TissuesIII. Distribution of Monoamines in Invertebrates and Vertebrates; IV. Synthesis of Monoamines in Invertebrates and Vertebrates; V. Storage, Release, and Reuptake of Monoamines; VI. Catabolism of Monoamine Neurotransmitters in Invertebrates and Vertebrates; VII. Conclusions; References; Chapter 7. Neurotransmitter Systems in Schizophrenia; I. Introduction; II. Etiology: Generic and Environmental; III. Neuropathology
edited by Ronald J. Bradley, R. Adron Harris.
Includes bibliographical references and index.
International review of neurobiology. Volume 38
International review of neurobiology ; 38