rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Drug-like properties
    sub title: concepts, structure design and methods : from ADME to toxicity optimization
  name:
    name part: Kerns, Edward Harvel.
    role:
      role term: creator
  name:
    name part: Di, Li.
  name:
    name part: ScienceDirect (Online service)
  type of resource: text
  genre: bibliography
  genre: Electronic books.
  origin info:
    place:
      place term: ne
    place:
      place term: Amsterdam
    place:
      place term: Boston
    publisher: Academic Press
    date issued: ©2008
    date issued: 2008
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource (xix, 526 pages, 2 unnumbered pages of plates) : illustrations (some color)
  abstract: Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. * Serves as an essential working handbook aimed at scientists and students in medicinal chemistry * Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies * Discusses improvements in pharmacokinetics from a practical chemist's standpoint.
  table of contents: Preface; Introductory Concepts; Physicochemical Properties; Disposition, Metabolism and Safety; Methods; Specific Topics; Answers to Problems; Appendix I: General References; Appendix II: Glossary.
  note: Edward H. Kerns and Li Di.
  note: Includes bibliographical references (page 492) and index.
  subject:
    topic: Pharmaceutical chemistry
  subject:
    topic: Drugs
    topic: Structure-activity relationships
  subject:
    topic: Drug development
  subject:
    topic: Drugs
    topic: Design
  subject:
    topic: Drugs
    topic: Side effects
  subject:
    topic: Pharmacokinetics
  subject:
    topic: Structure-activity relationships (Biochemistry)
  subject:
    topic: Drug Design
  subject:
    topic: Chemistry, Pharmaceutical
  subject:
    topic: Drug Evaluation, Preclinical
  subject:
    topic: Drug-Related Side Effects and Adverse Reactions
  subject:
    topic: Pharmaceutical Preparations
    topic: metabolism
  subject:
    topic: Pharmacokinetics
  subject:
    topic: Structure-Activity Relationship
  subject:
    topic: Chimie pharmaceutique
  subject:
    topic: Médicaments
    topic: Relations structure-activité
  subject:
    topic: Médicaments
    topic: Développement
  subject:
    topic: Médicaments
    topic: Conception
  subject:
    topic: Médicaments
    topic: Effets secondaires
  subject:
    topic: Pharmacocinétique
  subject:
    topic: Relations structure-activité (Biochimie)
  subject:
    topic: MEDICAL
    topic: Drug Guides
  subject:
    topic: MEDICAL
    topic: Pharmacology
  subject:
    topic: MEDICAL
    topic: Pharmacy
  subject:
    topic: MEDICAL
    topic: Nursing
    topic: Pharmacology
  subject:
    topic: Structure-activity relationships (Biochemistry)
  subject:
    topic: Pharmacokinetics
  subject:
    topic: Drugs
    topic: Side effects
  subject:
    topic: Drug development
  subject:
    topic: Drugs
    topic: Design
  subject:
    topic: Drugs
    topic: Structure-activity relationships
  subject:
    topic: Pharmaceutical chemistry
  classification: RS420 .K47 2008eb
  classification: 615/.19
  classification: QV 744 K395d 2008
  related item:
    title info:
      title: Drug-like properties
    name:
      name part: Kerns, Edward Harvel.
    origin info:
      publisher: Amsterdam ; Boston : Academic Press, ©2008
    identifier: (DLC) 2007035586
    identifier: (OCoLC)169452881
  related item:
    title info:
      title: Drug Discovery Bundle
  identifier: 9780123695208
  identifier: 0123695201
  identifier: 9780080557618
  identifier: 0080557619
  identifier: 130415:130518 Elsevier Science & Technology
  identifier: http://proxy.library.tamu.edu/login
  record info:
    record content source: OPELS
    record creation date: 081212
    record change date: 20260326155926.2
    record identifier: in00005735583
    language of cataloging:
      language term: eng