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Progress in nucleic acid research and molecular biology
1 online resource (xii, 370 pages) : illustrations
Praise for the Serial: "Full of interest not only for the molecular biologist - for whom the numerous references will be invaluable - but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell."--British Medical Journal Key Features * Provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology * Contributions from leaders in their fields * Abundant references
Cover; Contents; Abbreviations and Symbols; Some Articles Planned for Future Volumes; Chapter 1. Structure, Reactivity, and Biology of Double-Stranded RNA; I. Biological Origins of dsRNA; II. Experimental Criteria for dsRNA; III. Structure and Dynamics of dsRNA; IV. Protein Recognition of dsRNA; V. Chemical Stability of dsRNA; VI. Enzymatic Cleavage of dsRNA; VII. dsRNA Function in Prokaryotes; VIII. dsRNA Function in Eukaryotes; IX. dsRNA and the Interferon System; X. Cellular and Physiological Effects of dsRNA, and Therapeutic Application; XI. Conclusions and Prospects; References
Note Added in ProofChapter 2. Evolution, Expression, and Possible Function of a Master Gene for Amplification of an Interspersed Repeated DNA Family in Rodents; I. Evolution of the BC1 RNA Gene; II. The BC1 RNA Gene As a Master Gene for ID Repeats; III. Anatomical and Subcellular Distribution of BC1 RNA; IV. Transcriptional Regulation of the Rat BC1 RNA Gene; V. Speculations on BC1 RNA Function; References; Chapter 3. Nutritional and Hormonal Regulation of Expression of the Gene for Malic Enzyme; I. Nutritional State Regulates Fatty-acid Synthesis and Activities of Lipogenic Enzymes
II. The Animal ModelIII. Physiological Mechanisms; IV. Molecular Mechanisms; V. Mechanisms for Regulating Transcription; VI. Chromatin Structure; VII. cis-Acting Elements in the Malic-enzyme Gene; VIII. Summary; References; Chapter 4. Oxidative Chemical Nucleases; I. Chemistry of Scission; II. Reactivity of the Untargeted 2:1 1,10-Phenanthroline-cuprous Complex; III. Conformational Sensitivity; IV. (OP)2Cu+ as a Footprinting Reagent; V. Discovery of a New Class of Transcription Inhibitors; VI. Site-specific Targeting of DNA Scission; VII. Nucleic-acid-directed Scission
VIII. Protein-targeting of DNA ScissionIX. Conclusion; References; Chapter 5. The Decay of Bacterial Messenger RNA; I. Kinetics of Decay and Decay's Basic Paradigm; II. How mRNA Decays: Pathways and Determinants; III. Determinants of Decay; IV. Enzymes of mRNA Decay; V. Mechanism of mRNA Decay; References; Chapter 6. The Linker Histones and Chromatin Structure: New Twists; I. Linker Histones: Properties and Interactions with Other chromatin Components; II. The Importance of Linker Histones in Chromatin Fiber Structure; III. What Do We Know? What Do We Need to Learn?; References
Chapter 7. Development of Antisense and Antigene Oligonucleotide AnalogsI. Nuclease-resistant Antisense Oligonucleotide Analogs; Oligonucleoside Methylphosphonates; II. Antigene Oligonucleotide Analogs; III. Conclusion; References; Chapter 8. Hidden Infidelities of the Translational Stop Signal; I. What Is Unique about a Codon That Specifies Stop?; II. What Influences the Decoding of a Translational Stop Signal?; III. What Really Decodes the Stop Signal?; IV. What Is the Mechanism of Decoding of a Translational Stop Singnal?; V. Recoding at a Stop Codon
Includes bibliographical references and index.
Progress in nucleic acid research and molecular biology. Volume 52
Progress in nucleic acid research and molecular biology ; v. 52