http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
1 online resource (357 pages) : illustrations en noir.
This latest volume of the biannual serial continues rapid, current coverage of all aspect of the molecular basis of human cancer, functions of oncogenes, and research strategies of cancer drug development and treatment.
Cover; Contents; Contributors to Volume 63; Chapter 1. Foundations in Cancer Research: Alone on the Heart of the Earth: An Immunogeneticist's Journey into the Past; I. Part One: The Uncertainty Principle; II. Part Two: Interrogating the Sphinx; III. Part Three: Points of View; References; Chapter 2. Foundations in Cancer Research: Hemopoietic Regulators and Leukemia Development: A Personal Retrospective; I. Introduction; II. Background and Early in Vivo Work; III. Hemopoietic Clonal Cultures; IV. Colony-Stimulating Factors; V. Biological Actions of the Colony-Stimulating Factors
VI. Myeloid Leukemic Cells in CultureVII.Role of the Colony-Stimulating Factors in Initiation of Myeloid Leukemia; VIII. Membrane Receptors for Colonyy-Stimulating Factors; IX. Hemopoietic Regulators in the Context of Known Inducers of Leukemia; X. Role of Hemopoietic Regulators in Suppressing Myeloid Leukemia; XI. Recapitulation; XlI. The Future; References; Chapter 3. Map Kinases Erk1 and Erk2: Pleiotropic Enzymes in a Ubiquitous Signaling Network; I. Introduction; II. Homology of MAP Kinases with Proteinsin the Yeast Mating Pathway; III. Regulation of MAP Kinases
IV. Identification and Purification of MEKV. Ras and Heterotrimeric G Proteins Regulate the ERK Network; VI. Protein-Protein Interactions That Regulate the MAP Kinase Cascade; VII. MAP Kinases Phosphorylate Upstream Components of the Cascade; VIII. Substrates of ERKl and ERK2; IX. ERKl and ERK2 Are Essential Regulators of Cell Function; References; Chapter 4. How DNA Viruses Perturb Functional MHC Expression to Alter Immune Recognition; I. MHC Expression and Immune Recognition of Viral Antigens by T Cells; II. Poxviruses; III. Adenoviruses; IV. Herpesviruses: The Cytomegalovirus Model
V. Hepatitis B VirusVI. Papillomavirus; VII. Conclusions; References; Chapter 5. Viral Transformation of Human T Lymphocytes; I. Introduction; II. Transformation of Human T Helper Lymphocytes by Human T Cell Leukemia Virus; Ill. Developing a T-Lymphotropic Herpesvirus Vector; IV. Immortalization by Herpesvirus saimiri/HTLV Recombinants; V. Transformation of Human T Lymphocytes with Wild-Type Herpesvirus saimiri; VI. Growth Regulation and Antigen Specificity of Rhadinovirus-Transformed T Cell Lines and Clones; VII. Transforming Potential of the Herpesviral stp Oncogene
VIII. Concluding RemarksReferences; Chapter 6. Lymphomagenesis in Akr Mice: B Cell Lymphomas as a Model of Tumor Dormancy; I. Introduction; II. Identification of Potential Lymphoma Cells in AKR Mice; Ill. Enhanced T Cell Lymphoma Development Pathways; IV. The Level of Dormant PLCs Following Prevention of Spontaneous T Cell Lymphoma Development; V. Maintenance and Termination of the B-PLC Dormant State; VI. Ly-I+ (CD5+) B Cell Lymphoma Characteristics; VII. Concluding Remarks; References; Chapter 7. The Tumor Biology of Gastrin and Cholecystokinin; I. Introduction
Includes bibliographical references and index.