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|a 244320025
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|a 9780123740236
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|a 0123740231
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|a 139276:139413
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|a TXAM
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|a Hagel, Lars.
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| 245 |
1 |
0 |
|a Handbook of process chromatography :
|b development, manufacturing, validation and economics.
|
| 250 |
|
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|a 2nd ed. /
|b Lars Hagel, Günter Jagschies and Gail Sofer.
|
| 260 |
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|a London ;
|a Burlington, MA :
|b Academic,
|c 2008.
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|a 1 online resource (xvi, 363 pages) :
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|a This book will update the original edition published in 1997. Since the publication of the first edition, the biotechnology and biologics industries have gained extensive knowledge and experience in downstream processing using chromatography and other technologies associated with recovery and purification unit operations. This book will tie that experience together for the next generation of readers. Updates include: - sources and productivity - types of products made today - experiences in clinical and licensed products - economics - current status of validation - illustrations and tables - automated column packing - automated systems New topics include: - the use of disposables - multiproduct versus dedicated production - design principles for chromatography media and filters - ultrafiltration principles and optimization - risk assessments - characterization studies - design space - platform technologies - process analytical technologies (PATs) - biogenerics - comparability assessments Key Features: - new approaches to process optimiaztion - use of patform technologies - applying risk assessment to process design.
|
| 505 |
0 |
|
|a Preface -- Acknowledgements -- 1. Biopharmaceuticals Today -- 2. Process Capability and Production Scenarios -- 3. Process Design Concepts -- 4. Separation Technologies -- 5. Analysis -- 6. Cleaning and Sanitization -- 7. Validation -- 8. Economics -- 9. Basic Properties of Peptides, Proteons, Nucleic Acids, and Virus Particles -- 10. Optimization of Chromatographic Separations -- 11. Equipment -- 12. Column Packing -- Appendix A. Symbols and Definitions in Liquid Chromatography -- Appendix B. Dimensionless Numbers -- Appendix C. Activities for Biopharmaceutical Production from Genetically Engineered Mammalian Cells -- Appendix D. Simulations Using the Supplied Software.
|
| 500 |
|
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|a Previous edition: published as by G.K. Sofer and Lars Hagel. 1997.
|
| 500 |
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|a Includes CD-ROM.
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| 504 |
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|a Includes bibliographical references and index.
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| 588 |
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|a Print version record.
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| 650 |
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|a Chromatographic analysis
|x Industrial applications.
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|a Jagschies, Günter.
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|a Sofer, G. K.
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| 710 |
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|a ScienceDirect (Online service)
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|i Print version:
|a Hagel, Lars.
|t Handbook of process chromatography.
|b 2nd ed.
|d London ; Burlington, MA : Academic, 2008
|z 9780123740236
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|w (OCoLC)181420871
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|a Texas A&M University
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