RNA modification /
The presence of modified nucleotides in cellular RNAs has been known for decades and over 100 distinct RNA modifications have been characterized to date. While the exact role of many of these modifications is still unclear, many are highly conserved across evolution and most contribute to the overal...
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| Format: | eBook |
| Language: | English |
| Language Notes: | English. |
| Published: |
San Diego, California :
Academic Press/Elsevier,
©2007.
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| Series: | Methods in enzymology ;
v. 425. |
| Subjects: | |
| Online Access: | Connect to the full text of this electronic book |
| Summary: | The presence of modified nucleotides in cellular RNAs has been known for decades and over 100 distinct RNA modifications have been characterized to date. While the exact role of many of these modifications is still unclear, many are highly conserved across evolution and most contribute to the overall fitness of the organism. In recent years, new methods and bioinformatics approaches have been developed for the dissection of modification pathways and functions. These methods intersect a number of related fields, ranging from RNA processing to comparative genomics and systems biology. In addition, many of the techniques described in this volume have broad applicability, particularly in regards to the isolation, characterization, and reconstitution of ribonucleoprotein complexes, expanding the experimental repertoire available to all RNA researchers. |
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| Physical Description: | 1 online resource (xlii, 433 pages, 8 unnumbered pages of plates) : illustrations |
| Bibliography: | Includes bibliographical references and indexes. |
| ISBN: | 9780080550916 0080550916 0123741556 9780123741554 1281056979 9781281056979 9786611056971 6611056971 |
| ISSN: | 0076-6879 ; |