rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Design and optimization in organic synthesis
  name:
    name part: Carlson, Rolf
    name part: 1946-
    role:
      role term: creator
  name:
    name part: Carlson, Johan E.
    name part: 1973-
  name:
    name part: ScienceDirect (Online service)
  type of resource: text
  genre: bibliography
  genre: Electronic books.
  genre: CD-ROMs.
  origin info:
    place:
      place term: ne
    place:
      place term: Amsterdam
    place:
      place term: San Diego, CA
    publisher: Elsevier
    date issued: 2005
    edition: 2nd rev. and enl. ed.
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource (xx, 574 pages) : illustrations
  abstract: Revised, and updated Design and Optimization in Organic Synthesis presents strategies to explore experimental conditions and methodologies for systematic studies of entire reaction systems (substrates, reagent(s), catalyst(s), and solvents). Chemical phenomena are not usually the result of a single factor and this book describes how statistically designed methods can be used to analyse and evaluate synthetic procedures. The methodology is based on multivariate statistical techniques. The accompanying CD contains data tables and programmes. This book is essential reading for anyone working in process design and development in fine chemicals or the pharmaceutical industry, and is suitable for those with no experience in the field. * Contains recalculated models and redrawn figures, as well as new chapters on for example, the design of combinatorial libraries * Presents strategies to explore experimental conditions and methodologies * Enables the analysis and prediction of the best synthetic procedures.
  table of contents: Strategies on different levels in organic synthesis -- Experimental study of reaction conditions : initial remarks -- Models as tools -- General outline of screening experiments -- Two-level factorial designs -- Two-level fractional factorial designs -- Other designs for screening experiments -- Summary of screening experiments -- Optimisation -- Steepest ascent -- Simplex methods -- Response surface methods -- Reaction kinetics by sequential response surface modelling -- Summary of strategies for exploring the experimental space -- The reaction space -- Principal properties -- Strategies for the selection of test systems -- Quantitative relations : observed responses and experimental variations -- Exploring discrete variations : near-orthogonal experiments by singular value decomposition -- Optimization when there are several responses variables -- A method for determining suitable order of introducing reagents in "one-pot" procedures.
  note: Rolf Carlson, Johan E. Carlson.
  note: Includes bibliographical references and index.
  subject:
    topic: Organic compounds
    topic: Synthesis
  subject:
    topic: Composés organiques
    topic: Synthèse
  subject:
    topic: SCIENCE
    topic: Chemistry
    topic: Organic
  subject:
    topic: Organic compounds
    topic: Synthesis
  classification: QD262 .C32 2005eb
  classification: 547.2 C197d2005
  related item:
    title info:
      title: Design and optimization in organic synthesis
    name:
      name part: Carlson, Rolf, 1946-
    origin info:
      publisher: Amsterdam ; San Diego, CA : Elsevier, 2005
      edition: 2nd rev. and enl. ed.
    identifier: (OCoLC)59080831
  related item:
    title info:
      title: Data handling in science and technology ; v. 24
  identifier: 9780444515278
  identifier: 0444515275
  identifier: 9780080455273
  identifier: 0080455271
  identifier: 0444518851
  identifier: 2006355502
  identifier: 102789:102808 Elsevier Science & Technology
  identifier: http://proxy.library.tamu.edu/login
  record info:
    record content source: OPELS
    record creation date: 070806
    record change date: 20260326151830.5
    record identifier: in00005733069
    language of cataloging:
      language term: eng